SERPINA5

Gene Symbol	SERPINA5
Entrez Gene	5104
Alt Symbol	PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Other Description	acrosomal serine protease inhibitor|plasma serine protease inhibitor|plasminogen activator inhibitor III|plasminogen activator inhibitor-3|protein C inhibitor|serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Swissprots	Q9UG30 Q07616 P05154
Accessions	AAA02811 AAB30461 AAK27240 EAW81582 EAW81583 EAW81584 EAW81585 EAW81586 P05154 AI114432 AK096131 BAG53218 AK293192 BAG56732 AK298279 BAG60539 AK310869 AL080185 CAB45766 BC008915 AAH08915 DC394575 DQ893527 ABM84453 DQ896552 ABM87551 HY003178 J02639 AAA35688 S58545 AAB26244 U35464 AAB60386 NM_000624 NP_000615
Function	Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activato
Subcellular Location	Secreted, extracellular space {ECO:0000269|PubMed:1725227, ECO:0000269|PubMed:18467335, ECO:0000269|PubMed:7521127, ECO:0000269|PubMed:8536714, ECO:0000269|PubMed:9510955, ECO:0000269|PubMed:9556620}. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
Tissue Specificity	Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate. {ECO:0000269|PubMed:1372913, ECO:0000269|PubMed:14696115, ECO:0000269|PubMed:15140131, ECO:0000269|PubMed:17706750, ECO:0000269|PubMed:18467335, ECO:000026
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Protein C inhibitor full length protein - ab152068 from Abcam Category Protein Source HEK 293 cells Species Human

Human Protein C inhibitor full length protein - ab89362 from Abcam Category Protein Source E. coli Species Human

Human Protein C inhibitor full length protein - ab117168 from Abcam Category Protein Source E. coli Species Human

Human Protein C inhibitor peptide - ab64727 from Abcam Category Peptide

SERPINA5 / PCI Antibody Blocking Peptide - LS-E3902 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SERPINA5 / PCI Antibody Blocking Peptide - LS-E19342 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SERPINA5 / PCI Antibody Blocking Peptide - LS-E19343 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Serpin A5/Protein C Inhibitor Recombinant Protein - H00005104-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Serpin A5/Protein C Inhibitor Protein - NBP1-30282 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Species Human

SERPINA5-Antibody-N-term-Blocking-Peptide - BP16092a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Serpin A5, CF - 1266-PI-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, His20-Pro406, with a C-terminal 10-His tag

SERPINA5 Protein (OPPA02068) - OPPA02068 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human SERPINA5 protein - orb81358 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human Serpin A5 protein - orb49646 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Serpin A5 protein (His tag) - 80R-1216 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

SERPINA5 Blocking Peptide - 33R-5288 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SERPINA5 Blocking Peptide - 33R-9544 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PAI3 Blocking Peptide - abx064073 from Abbexa Category Peptide Species Human, Monkey

SERPINA5 (20-406, His-tag) - AR09302PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

SERPINA5 (20-406, His-tag) - AR09302PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

SERPINA5 - H00005104-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SERPINA5 - H00005104-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Serpin A5, 20-406 aa, Human, His-tag, E.coli - 01-2189 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Serpin A5, Human, Recombinant - 19-C535 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source HEK293 Species Human

SERPINA5 fusion protein - ag1078 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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