SERPINA5

Gene Symbol	SERPINA5
Entrez Gene	5104
Alt Symbol	PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI
Species	Human
Gene Type	protein-coding
Description	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Other Description	acrosomal serine protease inhibitor|plasma serine protease inhibitor|plasminogen activator inhibitor III|plasminogen activator inhibitor-3|protein C inhibitor|serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Swissprots	Q9UG30 Q07616 P05154
Accessions	AAA02811 AAB30461 AAK27240 EAW81582 EAW81583 EAW81584 EAW81585 EAW81586 P05154 AI114432 AK096131 BAG53218 AK293192 BAG56732 AK298279 BAG60539 AK310869 AL080185 CAB45766 BC008915 AAH08915 DC394575 DQ893527 ABM84453 DQ896552 ABM87551 HY003178 J02639 AAA35688 S58545 AAB26244 U35464 AAB60386 NM_000624 NP_000615
Function	Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary- type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activato
Subcellular Location	Secreted, extracellular space {ECO:0000269|PubMed:1725227, ECO:0000269|PubMed:18467335, ECO:0000269|PubMed:7521127, ECO:0000269|PubMed:8536714, ECO:0000269|PubMed:9510955, ECO:0000269|PubMed:9556620}. Note=Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
Tissue Specificity	Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate. {ECO:0000269|PubMed:1372913, ECO:0000269|PubMed:14696115, ECO:0000269|PubMed:15140131, ECO:0000269|PubMed:17706750, ECO:0000269|PubMed:18467335, ECO:000026
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SERPINA5-cDNA-Clone - DC02538 from Abgent, a WuXi AppTec company Prices $548.10 Sizes 10 µg Species Human Accession BC008915

SERPINA5 - MBS1270194 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC008915

human SERPINA5 ORF clone - CDCH078752 from Creative Biomart Species Human Accession NM_000624

human SERPINA5 ORF clone - CDCH078753 from Creative Biomart Species Human Accession NM_000624

human SERPINA5 ORF clone - CDCH078754 from Creative Biomart Species Human Accession NM_000624

human SERPINA5 ORF clone - CDCH078755 from Creative Biomart Species Human Accession NM_000624

Human Protein C Inhibitor Gene ORF cDNA clone in cloning vector - HG10309-M from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, N-His tag - HG10309-NH from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10309-CM from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10309-ACR from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid - HG10309-UT from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, C-HA tag - HG10309-CY from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10309-NF from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10309-NM from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10309-CF from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, N-HA tag - HG10309-NY from Sino Biological Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, C-His tag - HG10309-CH from Sino Biological Species Human

Human SERPINA5 ORF Clone (BC008915) - CDCS405799 from Creative biogene Species Human Accession P05154

Human SerpinA5 gene - orb90898 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human Protein C Inhibitor Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10309-ACG from Sino Biological Species Human

Search more