DOCK1

Gene Symbol	DOCK1
Entrez Gene	1793
Alt Symbol	DOCK180, ced5
Species	Human
Gene Type	protein-coding
Description	dedicator of cytokinesis 1
Other Description	180 kDa protein downstream of CRK|DOwnstream of CrK|dedicator of cytokinesis protein 1
Swissprots	A9Z1Z5 Q14185
Accessions	EAW49194 Q14185 AI951513 AK091673 AL157538 AW298149 BC084559 BC144632 BC146857 AAI46858 BP205399 BU556771 BU626553 BX482033 BX648342 CD104773 CF455012 CX163251 D50857 BAA09454 DA350224 XM_011539421 XP_011537723 XM_011539422 XP_011537724 XM_011539423 XP_011537725 XM_011539424 XP_011537726 XM_011539425 XP_011537727 XM_011539426 XP_011537728 NM_001290223 NP_001277152 NM_001380 NP_001371
Function	Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000269|PubMed:8657152}.
Subcellular Location	Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.
Tissue Specificity	Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Top Pathways	Focal adhesion, Bacterial invasion of epithelial cells, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DOCK1 full length protein - ab114754 from Abcam Category Protein Source Wheat germ Species Human

Human DOCK1 peptide - ab22812 from Abcam Category Peptide Species Human

Human DOCK1 protein fragment - ab114755 from Abcam Category Protein Source Wheat germ Species Human

DOCK180 / DOCK1 Antibody Blocking Peptide - LS-E25247 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DOCK1 Protein - H00001793-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human DOCK1 Protein - H00001793-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DOCK1 blocking peptide - GTX89965-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Human DOCK1 Protein - abx066282 from Abbexa Category Protein Source E.coli Species Human

DOCK1 Peptide - AC21-0074-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DOCK1 / DOCK180 - H00001793-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DOCK1 / DOCK180 - H00001793-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DOCK1 / DOCK180 - H00001793-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DOCK1 / DOCK180 - H00001793-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Dedicator Of Cytokinesis 1 (DOCK1), Human - 20-9145 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

DOCK1 Peptide - 45-489P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

DOCK1 fusion protein - ag18069 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DOCK1 fusion protein - ag16342 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DOCK1 - DOCK1-26153TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human DOCK1 - DOCK1-26951TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Dedicator Of Cytokinesis 1 (DOCK1) - RPG175Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

DOCK 180 (K1692) Peptide - BS3846P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Dedicator Of Cytokinesis 1 (DOCK1) - RPG175Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Dedicator of cytokinesis protein 1(DOCK1) ,partial - CSB-YP619864HU CSB-EP619864HU CSB-BP619864HU CSB-MP619864HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DOCK 180 (1700-1769) - sc-4481 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

Dedicator Of Cytokinesis 1 (DOCK1) - RPU141150 from Biomatik Category Protein Prices $225.50, $451.00, $676.50 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

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