| Gene Symbol |
DOCK1
|
| Entrez Gene |
1793
|
| Alt Symbol |
DOCK180, ced5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dedicator of cytokinesis 1
|
| Other Description |
180 kDa protein downstream of CRK|DOwnstream of CrK|dedicator of cytokinesis protein 1
|
| Swissprots |
A9Z1Z5 Q14185
|
| Accessions |
EAW49194 Q14185 AI951513 AK091673 AL157538 AW298149 BC084559 BC144632 BC146857 AAI46858 BP205399 BU556771 BU626553 BX482033 BX648342 CD104773 CF455012 CX163251 D50857 BAA09454 DA350224 XM_011539421 XP_011537723 XM_011539422 XP_011537724 XM_011539423 XP_011537725 XM_011539424 XP_011537726 XM_011539425 XP_011537727 XM_011539426 XP_011537728 NM_001290223 NP_001277152 NM_001380 NP_001371
|
| Function |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000269|PubMed:8657152}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
|
| Top Pathways |
Focal adhesion, Bacterial invasion of epithelial cells, Regulation of actin cytoskeleton
|