S100B

Gene Symbol	S100B
Entrez Gene	525716
Alt Symbol	-
Species	Bovine
Gene Type	protein-coding
Description	S100 calcium binding protein B
Other Description	S-100 protein beta chain\|S-100 protein subunit beta\|S100 calcium-binding protein B\|S100 protein, beta polypeptide\|protein S100-B
Swissprots	Q3ZBY1 A4IFR6 P02638
Accessions	DAA32950 P02638 BC103041 AAI03042 BC134727 AAI34728 DQ195377 ABA39829 NM_001034555 NP_001029727
Function	Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

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