OTUD5

Gene Symbol OTUD5
Entrez Gene 55593
Alt Symbol DUBA
Species Human
Gene Type protein-coding
Description OTU deubiquitinase 5
Other Description OTU domain containing 5|OTU domain-containing protein 5|deubiquinating enzyme A|deubiquitinating enzyme A
Swissprots B4DGG7 Q4KMN9 G5E9D7 Q9H650 Q96G74 Q9NT65 Q9H9U0 Q8N6T5
Accessions EAW50722 EAW50723 EAW50724 EAW50725 EAW50726 EAW50727 Q96G74 AK022612 BAB14131 AK026260 BAB15416 AK294590 BAG57778 AL137509 CAB70778 BC009917 AAH09917 BC011738 BC028225 AAH28225 BC098440 AAH98440 BM797460 BY799160 CB243128 CN368451 DA237046 DC419901 XM_005272622 XP_005272679 XM_005278039 XP_005278096 XM_005278042 XP_005278099 XM_006724537 XP_006724600 XM_011543932 XP_011542234 XM_011543933 XP_011542235 XM_011543934 XP_011542236 NM_001136157 NP_001129629 NM_001136158 NP_001129630 NM_001136159 NP_001129631 NM_017602 NP_060072
Function Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}.
Tissue Specificity Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. {ECO:0000269|PubMed:17991829}.
Top Pathways RIG-I-like receptor signaling pathway

OTUD5 (G-13) - sc-168865 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-OTUD5 antibody - ab77087 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-OTUD5 antibody (ab77087) at 1 µg/mlLane 2 : Anti-OTUD5 antibody (ab77087) at 2 µg/mlLane 1 : Human kidney lysateLane 2 : Human kidney lysateLysates/proteins at 15 µg per lane.

Anti-OTUD5 antibody - ab176727 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of immunoprecipitate of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), labeling OTUD5 using ab176727 used for WB at 1 µg/ml and used for IP at 3 µg/mg lysate, using chemiluminescence with exposure times of 10 seconds.

Anti-OTUD5 antibody - ab154670 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD5 Antibody (aa414-426) - LS-C87310 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-OTUD5 Antibody (aa150-500) - LS-C289626 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD5 Antibody (aa521-571) - LS-C289629 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OTUD5 Antibody (aa550-600) - LS-C148579 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of DUBA in formalin-fixed, paraffin-embedded human liver tissue using an isotype control (top) and LS-C148579 (bottom) at 5 ug/ml.

Anti-OTUD5 Antibody (C-Terminus) - LS-C83929 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of OTUD5 in Human Kidney cells with OTUD5 antibody at 20 ug/ml.

OTUD5 Antibody - NBP2-24634 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: OTUD5 Antibody [NBP2-24634] - Analysis of DUBA in human liver lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse liver lysate and 4) rat liver lysate using this antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

OTUD5 Antibody - NBP1-76943 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

OTUD5 Antibody - NBP1-49937 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OTUD5 Antibody [NBP1-49937] - Detection of Human and Mouse DUBA by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg) and mouse NIH3T3 (M; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-DUBA antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. DUBA was also immunoprecipitated by rabbit anti-DUBA antibody which recognizes a downstream epitope. For blotting immunoprecipitated DUBA was used. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).

OTUD5 Antibody - NBP1-49936 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OTUD5 Antibody [NBP1-49936] - Detection of Human and Mouse DUBA by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg) and mouse NIH3T3 (M; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-DUBA antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. DUBA was also immunoprecipitated by rabbit anti-DUBA antibody which recognizes a downstream epitope. For blotting immunoprecipitated DUBA was used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).

OTUD5 Antibody - NBP2-19643 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OTUD5 Antibody [NBP2-19643] - Sample (30 ug of whole cell lysate) A: A431 10% SDS PAGE gel, diluted at 1:1000.

OTUD5 Antibody - NBP1-20909 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-OTUD5 antibody produced in rabbit - HPA017375 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OTUD5: <B>Cat. No. HPA017375</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human rectum shows cytoplasmic positivity in glandular cells.

Anti-OTUD5 antibody produced in rabbit - SAB2701477 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-OTUD5: <B>Cat. No. SAB2701477</B>: Western Blot analysis of OTUD5 in extracts from <B>Lanes</B><BR/>A. A431 using <B>Cat. No. SAB2701477</B> at a 1:1000 dilution.

Anti-OTUD5 antibody produced in rabbit - SAB3500324 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OTUD5: <B>Cat. No. SAB3500324</B>: Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 μg/mL.

DUBA-Antibody-internal-region - AF2790a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

DUBA antibody, Internal - GTX88701 from GeneTex

Prices $239.00
Sizes 100 μg
Host Goat
Clonality Polyclonal

OTUD5 antibody [C1C3] - GTX120546 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-OTUD5 antibody [C1C3] used in Western blot. GTX120546

OTUD5 antibody - orb75067 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of human kidney lysate at (A) 1 and (B) 2 ug/mL using OTUD5 antibody

OTUD5 antibody - orb19896 from Biorbyt

Prices $408.00
Sizes 100 μg
Host Goat
Clonality Polyclonal

OTUD5 Antibody (OAEB00672) - OAEB00672 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

OTUD5 (C-term) antibody - AP26191PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 μg/ml.
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