Gene Symbol | KSR1 |
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Entrez Gene | 8844 |
Alt Symbol | KSR, RSU2 |
Species | Human |
Gene Type | protein-coding |
Description | kinase suppressor of ras 1 |
Other Description | kinase suppressor of Ras 1 |
Swissprots | F8WEA9 Q13476 Q8IVT5 H7BYU0 |
Accessions | CAE84533 CAE84534 EAW51034 EAW51035 Q8IVT5 AK095721 AK124344 AK130719 BAC85413 BC035488 BC037586 BC042106 AAH42106 BC167812 AAI67812 BI829205 BX396814 U43586 AAC50354 XM_006722151 XP_006722214 XM_006722152 XP_006722215 XM_006722154 XP_006722217 XM_011525428 XP_011523730 XM_011525429 XP_011523731 XM_011525430 XP_011523732 XM_011525431 XP_011523733 XM_011525432 XP_011523734 XM_011525433 XP_011523735 XM_011525434 XP_011523736 XM_011525435 XP_011523737 XM_011525436 XP_011523738 XM_011525437 XP_011523739 XR_934587 XR_934588 XR_934589 NM_014238 NP_055053 |
Function | Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery (By similarity). {ECO:0000250}. |
Top Pathways | Tuberculosis |
Active human KSR1 protein fragment - ab190396 from Abcam
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Human KSR1 protein fragment - ab152923 from Abcam
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KSR1 Antibody Blocking Peptide - LS-E3018 from LifeSpan Bioscience
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KSR1 Antibody Blocking Peptide - LS-E8762 from LifeSpan Bioscience
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KSR1 Antibody Blocking Peptide - LS-E9285 from LifeSpan Bioscience
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Recombinant Human KSR1 Protein - H00008844-Q01 from Novus Biologicals
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KSR-Antibody-N-term-E174-Blocking-peptide - BP7202a from Abgent, a WuXi AppTec company
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KSR1-Antibody-N-term-A7-Blocking-Peptide - BP7812a from Abgent, a WuXi AppTec company
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Kinase suppressor of Ras 1 - H00008844-Q01-10 from Acris Antibodies
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Kinase suppressor of Ras 1 - H00008844-Q01-25 from Acris Antibodies
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Recombinant Human KSR1 (A635F), GST-tagged - KSR1-62H from Creative Biomart
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Recombinant Human KSR1 (L639F), GST-tagged - KSR1-63H from Creative Biomart
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Recombinant Human KSR1, GST-tagged - KSR1-34H from Creative Biomart
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Recombinant Human KSR1 (Active), GST-tagged - KSR1-1422H from Creative Biomart
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KSR (R386) Peptide - BS1707P from Bioworld Technology
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p-Ksr-1 (S392) Peptide - BS4460P from Bioworld Technology
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Recombinant Human Kinase suppressor of Ras 1(KSR1) ,partial - CSB-YP012695HU CSB-EP012695HU CSB-BP012695HU CSB-MP012695HU from Cusabio
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KSR1 Blocking Peptide - abx161660 from Abbexa
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Phospho-KSR1-S392 Peptide - abx165162 from Abbexa
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Phospho-KSR1-S404 Peptide - abx165163 from Abbexa
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KSR1 Recombinant Protein Antigen - NBP1-82863PEP from Novus Biologicals
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KSR-Antibody-C-term-Blocking-peptide - BP7202b from Abgent, a WuXi AppTec company
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KSR1 Peptide, Human - M34GP08494H from Creative Peptides
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KSR1 Blocking Peptide - CBP4449 from Cohesion Biosciences
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KSR1 Blocking Peptide - orb392794 from Biorbyt
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