HYOU1

Gene Symbol HYOU1
Entrez Gene 10525
Alt Symbol GRP-170, Grp170, HSP12A, ORP-150, ORP150
Species Human
Gene Type protein-coding
Description hypoxia up-regulated 1
Other Description 150 kDa oxygen-regulated protein|170 kDa glucose-regulated protein|hypoxia up-regulated protein 1|oxygen regulated protein (150kD)
Swissprots B7Z909 Q2I204 A8C1Z0 Q53H25 Q9Y4L1
Accessions ACA06002 BAF80348 EAW67440 EAW67441 EAW67442 EAW67443 Q9Y4L1 AA580314 AK127324 BAG54482 AK222756 BAD96476 AK294905 BAH11920 AK297260 BAH12532 AK299648 BAH13088 AK301514 BAH13502 AK304264 BAH14145 AK307624 AK314178 BAG36860 BC004560 AAH04560 BC017726 AAH17726 BC072436 AAH72436 BE733065 BE791468 BP236985 BP358970 CR749610 CAH18405 DC364982 DQ350134 ABC75106 DQ372932 ABD14370 HY089857 U65785 AAC50947 XM_005271392 XP_005271449 XM_005271393 XP_005271450 XM_005271394 XP_005271451 XM_011542557 XP_011540859 XM_011542558 XP_011540860 XM_011548778 XP_011547080 XM_011548779 XP_011547081 XM_011548780 XP_011547082 XM_011548781 XP_011547083 XM_011548782 XP_011547084 XR_947790 XR_953214 NM_001130991 NP_001124463 NM_006389 NP_006380
Function Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269|PubMed:10037731}.
Subcellular Location Endoplasmic reticulum lumen.
Tissue Specificity Highly expressed in tissues that contain well- developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
Top Pathways Protein processing in endoplasmic reticulum

HYOU1 Antibody - 13452 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using HYOU1 Antibody.

ORP150 (A-3) - sc-398224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ORP150 (A-3): sc-398224. Western blot analysis of ORP150 expression in HeLa (A), MCF7 (B), Hep G2 (C) and K-562 (D) whole cell lysates.

ORP150 (C-9) - sc-398110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ORP150 (C-9): sc-398110. Western blot analysis of ORP150 expression in HeLa (A), MCF7 (B), SH-SY5Y (C), Hep G2 (D) and K-562 (E) whole cell lysates.

ORP150 (N-15) - sc-243686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ORP150 (N-15): sc-243686. Western blot analysis of ORP150 expression in HeLa whole cell lysate.

ORP150 (E-16) - sc-243687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ORP150 antibody - ab125281 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ORP150 antibody (ab125281) at 1/500 dilution + Hypoxic Mouse brain tissue lysate

Anti-ORP150 antibody - ab56680 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ORP150 antibody (ab56680) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human salivary gland.

Anti-ORP150 antibody - ab85233 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ORP150 antibody (ab85233) at 1/50 dilution + 293 cell line lysate at 35 µg

Anti-ORP150 antibody [6F7] - ab117523 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6F7
ab117523, at 5 µg/ml, staining ORP150 in Formalin-fixed, Paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-ORP150 antibody [EP5891] - ab134944 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP5891
All lanes : Anti-ORP150 antibody [EP5891] (ab134944) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : MCF7 cell lysateLane 4 : HepG2 cell lysateLane 5 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-ORP150 antibody [EPR5890] - ab124884 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5890
Overlay histogram showing HepG2 cells stained with ab124884 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab124884, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-ORP150 antibody - C-terminal - ab151406 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ORP150 antibody - C-terminal (ab151406) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-HYOU1 / ORP150 Antibody (clone 2F07) - LS-C193594 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F07

Anti-HYOU1 / ORP150 Antibody (aa899-948) - LS-C116333 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HYOU1 / ORP150 antibody LS-C116333 Western blot of RPMI-8226 cell lysate.

Anti-HYOU1 / ORP150 Antibody (aa695-994, Biotin) - LS-C299593 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HYOU1 / ORP150 Antibody (aa695-994, FITC) - LS-C304454 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HYOU1 / ORP150 Antibody - LS-C308359 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HYOU1 / ORP150 Antibody (aa901-1000, Azide-free) - LS-C327598 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-HYOU1 / ORP150 Antibody (aa695-994) - LS-C294563 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant HYOU1 / ORP150.

Anti-HYOU1 / ORP150 Antibody - LS-C334837 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using HYOU1 antibody.

Anti-HYOU1 / ORP150 Antibody (clone 6F7) IHC-plus™ - LS-B5445 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6F7
Anti-HYOU1 / ORP150 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5445 concentration 5 ug/ml.

Anti-HYOU1 / ORP150 Antibody (Internal, clone EPR5890) IHC-plus™ - LS-B6661 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5890
Anti-HYOU1 / ORP150 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6661 dilution 1:50.

Anti-HYOU1 / ORP150 Antibody (C-Terminus, clone EP5891) - LS-C154718 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP5891
IHC of paraffin-embedded human liver tissue using anti-HYOU1 / ORP150 / ORP150 antibody.

Anti-HYOU1 / ORP150 Antibody (aa274-303) - LS-C100905 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with HYOU1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-HYOU1 / ORP150 Antibody (C-Terminus) IHC-plus™ - LS-B3175 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HYOU1 / ORP150 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3175 concentration 5 ug/ml.
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