DBT

Gene Symbol DBT
Entrez Gene 1629
Alt Symbol BCATE2, BCKAD-E2, BCKADE2, BCOADC-E2, E2, E2B
Species Human
Gene Type protein-coding
Description dihydrolipoamide branched chain transacylase E2
Other Description 52 kDa mitochondrial autoantigen of primary biliary cirrhosis|BCKAD E2 subunit|E2 component of branched chain alpha-keto acid dehydrogenase complex|branched chain 2-oxo-acid dehydrogenase complex component E2|branched chain acyltransferase, E2 component|branched-chain alpha-keto acid dehydrogenase complex component E2|dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex|dihydrolipoyl transacylase|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase|lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial|lipoamide acyltransferase component of mitochondrial branched-chain alpha-keto acid dehydrogenase complex|mitochondrial branched chain alpha-keto acid dehydrogenase transacylase subunit (E2b)
Swissprots B2R811 P11182 Q5VVL8
Accessions CAA48225 EAW72963 P11182 AK024946 AK303941 BAG64869 AK313191 BAG36008 BC016675 AAH16675 BC030002 BT007372 AAP36036 DA274670 J03208 AAA35589 M19301 AAA59200 M27093 AAA64512 X57677 X66785 CAA47285 XM_005270545 XP_005270602 XM_005270546 XP_005270603 XR_946560 NM_001918 NP_001909
Function The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.
Subcellular Location Mitochondrion matrix.
Top Pathways Valine, leucine and isoleucine degradation

DBT CRISPR/Cas9 KO Plasmid (h) - sc-410755 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT HDR Plasmid (h) - sc-410755-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT Double Nickase Plasmid (h) - sc-410755-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT Double Nickase Plasmid (h2) - sc-410755-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT CRISPR Activation Plasmid (h) - sc-410755-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT CRISPR Activation Plasmid (h2) - sc-410755-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT Lentiviral Activation Particles (h) - sc-410755-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT Lentiviral Activation Particles (h2) - sc-410755-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DBT siRNA (h) - sc-88212 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DBT shRNA Plasmid (h) - sc-88212-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DBT shRNA (h) Lentiviral Particles - sc-88212-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU035851 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6954 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6954 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DBT siRNA (Human) - CRH1146 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DBT - MBS8225697 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DBT (NM_001918.3) - SHH274817 from Creative biogene

Category siRNA
Species Reactivities Human

Human DBT siRNA - orb261648 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DBT shRNA Plasmid (Human) - CHH1146 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DBT miRNA 3'UTR clone - MiUTR4H-TG11049 from Creative biogene

Species Reactivities Human
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