Gene Symbol | MPLKIP |
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Entrez Gene | 136647 |
Alt Symbol | ABHS, C7orf11, ORF20 |
Species | Human |
Gene Type | protein-coding |
Description | M-phase specific PLK1 interacting protein |
Other Description | M-phase-specific PLK1-interacting protein|Russell-Silver syndrome region|TTD non-photosensitive 1 protein |
Swissprots | Q8TAP9 |
Accessions | EAL23999 EAW94134 Q8TAP9 AK290098 BAF82787 BC026265 AAH26265 BG501110 HQ447766 ADQ32251 NM_138701 NP_619646 |
Function | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}. |
Subcellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase. |
Tissue Specificity | Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles. {ECO:0000269|PubMed:11829489, ECO:0000269|PubMed:15645389}. |
TTDN1 CRISPR/Cas9 KO Plasmid (h) - sc-414434 from Santa Cruz Biotechnology
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TTDN1 HDR Plasmid (h) - sc-414434-HDR from Santa Cruz Biotechnology
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TTDN1 Double Nickase Plasmid (h) - sc-414434-NIC from Santa Cruz Biotechnology
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TTDN1 Double Nickase Plasmid (h2) - sc-414434-NIC-2 from Santa Cruz Biotechnology
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TTDN1 CRISPR Activation Plasmid (h) - sc-414434-ACT from Santa Cruz Biotechnology
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TTDN1 CRISPR Activation Plasmid (h2) - sc-414434-ACT-2 from Santa Cruz Biotechnology
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TTDN1 Lentiviral Activation Particles (h) - sc-414434-LAC from Santa Cruz Biotechnology
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TTDN1 Lentiviral Activation Particles (h2) - sc-414434-LAC-2 from Santa Cruz Biotechnology
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TTDN1 siRNA (h) - sc-76770 from Santa Cruz Biotechnology
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TTDN1 shRNA Plasmid (h) - sc-76770-SH from Santa Cruz Biotechnology
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TTDN1 shRNA (h) Lentiviral Particles - sc-76770-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU130871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5079 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5079 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02204 from Sigma-Aldrich
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MPLKIP siRNA (Human) - CRJ5190 from Cohesion Biosciences
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shRNA set against Human C7orf11 (NM_138701.3) - SHH252393 from Creative biogene
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Human MPLKIP siRNA - orb275691 from Biorbyt
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MPLKIP shRNA Plasmid (Human) - CHJ5190 from Cohesion Biosciences
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MPLKIP miRNA 3'UTR clone - MiUTR3H-10466 from Creative biogene
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