Gene Symbol | NKAP |
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Entrez Gene | 79576 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | NFKB activating protein |
Other Description | NF-kappa-B-activating protein|NF-kappaB activating protein |
Swissprots | Q9H638 Q96BQ2 Q6IPW6 Q8N5F7 |
Accessions | EAW89838 Q8N5F7 AK026279 BAB15428 AK094446 AL832118 AY388958 AAQ90402 BC000940 BC012770 BC015354 AAH15354 BC016783 AAH16783 BC018968 AAH18968 BC032442 AAH32442 BC071686 AAH71686 HQ448222 ADQ32702 NM_024528 NP_078804 |
Function | Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. {ECO:0000269|PubMed:14550261, ECO:0000269|PubMed:19409814}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:14550261}. |
NKAP CRISPR/Cas9 KO Plasmid (h) - sc-413177 from Santa Cruz Biotechnology
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NKAP HDR Plasmid (h) - sc-413177-HDR from Santa Cruz Biotechnology
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NKAP Double Nickase Plasmid (h) - sc-413177-NIC from Santa Cruz Biotechnology
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NKAP Double Nickase Plasmid (h2) - sc-413177-NIC-2 from Santa Cruz Biotechnology
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NKAP CRISPR Activation Plasmid (h) - sc-413177-ACT from Santa Cruz Biotechnology
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NKAP CRISPR Activation Plasmid (h2) - sc-413177-ACT-2 from Santa Cruz Biotechnology
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NKAP Lentiviral Activation Particles (h) - sc-413177-LAC from Santa Cruz Biotechnology
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NKAP Lentiviral Activation Particles (h2) - sc-413177-LAC-2 from Santa Cruz Biotechnology
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NKAP siRNA (h) - sc-90888 from Santa Cruz Biotechnology
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NKAP shRNA Plasmid (h) - sc-90888-SH from Santa Cruz Biotechnology
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NKAP shRNA (h) Lentiviral Particles - sc-90888-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU110601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15317 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15317 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00219 from Sigma-Aldrich
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NKAP siRNA (Human) - CRJ2403 from Cohesion Biosciences
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shRNA set against Human NKAP (NM_024528.3) - SHH352664 from Creative biogene
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Human NKAP siRNA - orb272904 from Biorbyt
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NKAP shRNA Plasmid (Human) - CHJ2403 from Cohesion Biosciences
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NKAP miRNA 3'UTR clone - MiUTR3H-02933 from Creative biogene
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