| Gene Symbol |
CX3CR1
|
| Entrez Gene |
1524
|
| Alt Symbol |
CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X3-C motif) receptor 1
|
| Other Description |
C-X3-C CKR-1|CMK-BRL-1|CMK-BRL1|CX3C chemokine receptor 1|G protein-coupled receptor 13|G-protein coupled receptor 13|beta chemokine receptor-like 1|chemokine (C-C) receptor-like 1|chemokine (C-X3-C) receptor 1|fractalkine receptor
|
| Swissprots |
P49238 J3KP17 B2R5Z4 A0N0N6
|
| Accessions |
AAK08627 ABK41927 ABS29268 EAW64575 EAW64576 P49238 AI400350 AK225764 AK307911 AK312373 BAG35291 BC017855 BC028078 AAH28078 BG541473 DA396634 DA406242 DB274136 DQ891063 ABM81989 DQ894243 ABM85169 U20350 AAA91783 U28934 AAA87032 NM_001171171 NP_001164642 NM_001171172 NP_001164643 NM_001171174 NP_001164645 NM_001337 NP_001328
|
| Function |
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in lymphoid and neural tissues.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|
![Western Blot: CX3CR1 Overexpression Lysate (Adult Normal) [NBL1-09619] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CX3CR1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/9884_CX3CR1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09619-img0002.jpg)