| Gene Symbol | USP1 |
|---|---|
| Entrez Gene | 7398 |
| Alt Symbol | UBP |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin specific peptidase 1 |
| Other Description | deubiquitinating enzyme 1|hUBP|ubiquitin carboxyl terminal hydrolase 1|ubiquitin carboxyl-terminal hydrolase 1|ubiquitin specific processing protease 1|ubiquitin specific protease 1|ubiquitin thioesterase 1|ubiquitin thiolesterase 1|ubiquitin-specific-processing protease 1 |
| Swissprots | A0PJ95 Q05BX7 Q9UFR0 Q59H66 D3DQ57 O94782 Q9UNJ3 |
| Accessions | EAX06585 EAX06586 O94782 AB014458 BAA34703 AB208893 BAD92130 AF117386 AAD11441 AK096788 AK312423 BAG35333 AL117503 CAB55967 AL117575 CAB55999 AL599240 AM392756 CAL37634 BC011881 BC018745 AAH18745 BC023216 BC032364 AAH32364 BC040140 BC050525 AAH50525 BI463072 BQ018843 BQ186837 NM_001017415 NP_001017415 NM_001017416 NP_001017416 NM_003368 NP_003359 |
| Function | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. {ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:18082604}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15694335}. |
| Top Pathways | Fanconi anemia pathway |