PTPN7
| Gene Symbol | PTPN7 |
|---|---|
| Entrez Gene | 5778 |
| Alt Symbol | BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, non-receptor type 7 |
| Other Description | dual specificity phosphatase 1|hematopoietic protein-tyrosine phosphatase|protein-tyrosine phosphatase LC-PTP|protein-tyrosine phosphatase, nonreceptor-type, stress induced|tyrosine-protein phosphatase non-receptor type 7 |
| Swissprots | Q53XK4 P35236 Q9BV05 B3KXE1 Q5SXQ0 Q5SXQ1 |
| Accessions | EAW91400 EAW91401 EAW91402 EAW91403 EAW91404 EAW91405 P35236 AF394064 AAM69538 AK127214 BAG54453 AK225920 AK293186 BAG56727 AK301051 BAG62662 AK301757 BAG63218 AK301980 BAG63388 AK302869 BAG64051 AK311661 BC001746 AAH01746 BG340453 BT009848 AAP88850 D11327 BAA01946 DC399028 M64322 AAA59531 S78090 XM_011509819 XP_011508121 XM_011509820 XP_011508122 XM_011509821 XP_011508123 XM_011509822 XP_011508124 XM_011509823 XP_011508125 XM_011509824 XP_011508126 XR_921906 NM_001199797 NP_001186726 NM_002832 NP_002823 NM_080588 NP_542155 NR_037663 NR_037664 NM_080589 |
| Function | Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. {ECO:0000269|PubMed:10206983, ECO:0000269|PubMed:10559944, ECO:0000269|PubMed:10702794, ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918, ECO:0000269|PubMed:9624114}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14613483}. Cytoplasm, cytoskeleton {ECO:0000250}. |
| Tissue Specificity | Expressed exclusively in thymus and spleen. {ECO:0000269|PubMed:1510684, ECO:0000269|PubMed:1530918}. |
| Top Pathways | MAPK signaling pathway |
HePTP CRISPR/Cas9 KO Plasmid (h) - sc-418020 from Santa Cruz Biotechnology
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HePTP HDR Plasmid (h) - sc-418020-HDR from Santa Cruz Biotechnology
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HePTP Double Nickase Plasmid (h) - sc-418020-NIC from Santa Cruz Biotechnology
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HePTP Double Nickase Plasmid (h2) - sc-418020-NIC-2 from Santa Cruz Biotechnology
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HePTP CRISPR Activation Plasmid (h) - sc-418020-ACT from Santa Cruz Biotechnology
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HePTP CRISPR Activation Plasmid (h2) - sc-418020-ACT-2 from Santa Cruz Biotechnology
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HePTP Lentiviral Activation Particles (h) - sc-418020-LAC from Santa Cruz Biotechnology
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HePTP Lentiviral Activation Particles (h2) - sc-418020-LAC-2 from Santa Cruz Biotechnology
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HePTP siRNA (h) - sc-43830 from Santa Cruz Biotechnology
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HePTP shRNA Plasmid (h) - sc-43830-SH from Santa Cruz Biotechnology
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HePTP shRNA (h) Lentiviral Particles - sc-43830-V from Santa Cruz Biotechnology
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PTPN7 RNAi - H00005778-R08 from Novus Biologicals
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PTPN7 RNAi - H00005778-R07 from Novus Biologicals
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PTPN7 RNAi - H00005778-R09 from Novus Biologicals
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MISSION® esiRNA - EHU086501 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0773 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1090 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1092 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1091 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0774 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0772 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17703 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17703 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10176 from Sigma-Aldrich
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PTPN7 siRNA (Human) - CRH3902 from Cohesion Biosciences
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