TTC8

Gene Symbol TTC8
Entrez Gene 123016
Alt Symbol BBS8, RP51
Species Human
Gene Type protein-coding
Description tetratricopeptide repeat domain 8
Other Description Bardet-Biedl syndrome type 8|TPR repeat protein 8|tetratricopeptide repeat protein 8
Swissprots Q86U26 B3KWA5 Q8TAM2 Q96DG8 A6NFG2 Q86TV9 Q8NDH9 Q67B97 Q86SY0
Accessions EAW81395 EAW81396 EAW81397 EAW81398 EAW81399 EAW81400 EAW81401 EAW81402 Q8TAM2 AF086168 AK093891 BAG52780 AK124675 BAG54067 AK296077 BAG58833 AK315772 AL833901 CAD38757 AY366523 AAR02192 AY366524 AAR02193 AY373972 AAR19043 BC001563 AAH01563 BC026351 AAH26351 BC095433 AAH95433 BG330023 BU738965 BX161472 CAD61928 BX247959 CAD62299 BX248071 CAD62360 BX248248 CAD62576 BX537546 XM_006720035 XP_006720098 XM_006720037 XP_006720100 XM_011536432 XP_011534734 XM_011536433 XP_011534735 XM_011536434 XP_011534736 XM_011536435 XP_011534737 NM_001288781 NP_001275710 NM_001288782 NP_001275711 NM_001288783 NP_001275712 NM_144596 NP_653197 NM_198309 NP_938051 NM_198310 NP_938052
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Tissue Specificity Widely expressed.

Human TTC8 full length protein - ab165194 from Abcam

Category Protein
Source Wheat germ
Species Human
ab165194 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human TTC8 protein fragment - ab165195 from Abcam

Category Protein
Source Wheat germ
Species Human
ab165195 on a 12.5% SDS-PAGE stained with Coomassie Blue.

TTC8 Antibody Blocking Peptide - LS-E4503 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

TTC8 Antibody Blocking Peptide - LS-E27348 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

TTC8 Antibody Blocking Peptide - LS-E17785 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human TTC8 Protein - H00123016-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

TTC8 Partial Recombinant Protein - H00123016-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

TTC8-Antibody-N-term-Blocking-Peptide - BP16824a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

TTC8 blocking peptide - GTX88117-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Mouse, Dog, Pig, Bovine

TTC8 Immunizing peptide - orb59824 from Biorbyt

Category Peptide
Prices $247.00
Sizes 100 μg
Species Human, Mouse, Rat

TTC8 Blocking Peptide - 33R-2599 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

TTC8 Peptide - AC21-2171-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

TTC8 - H00123016-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

TTC8 - H00123016-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

TTC8 - H00123016-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

TTC8 Peptide - 42-571P from ProSci

Category Peptide
Species Human

TTC8 fusion protein - Ag3186 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human TTC8, GST-tagged - TTC8-3477H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Tetratricopeptide repeat protein 8(TTC8) - CSB-YP848389HU CSB-EP848389HU CSB-BP848389HU CSB-MP848389HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

TTC8 / BBS8 (transcript variant 2) - TP310638 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
TTC8 / BBS8

Tetratricopeptide repeat protein 8 (TTC8), Recombinant Protein - MBS1320215 from MyBioSource

Category Protein
Prices $1,335.00, $1,335.00, $1,555.00, $1,555.00, $2,210.00, $2,210.00, $2,670.00, $2,670.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

TTC8, Peptide - MBS427291 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Mouse, Dog, Bovine, Pig

TTC8 Protein - NBP1-88688PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

TTC8 Peptide, Human - M34GP16814H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

TTC8 fusion protein - Ag21189 from Proteintech Group

Category Protein
Source E. coli -derived, PET30a
Species Human
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