TTC8

Gene Symbol	TTC8
Entrez Gene	123016
Alt Symbol	BBS8, RP51
Species	Human
Gene Type	protein-coding
Description	tetratricopeptide repeat domain 8
Other Description	Bardet-Biedl syndrome type 8|TPR repeat protein 8|tetratricopeptide repeat protein 8
Swissprots	Q86U26 B3KWA5 Q8TAM2 Q96DG8 A6NFG2 Q86TV9 Q8NDH9 Q67B97 Q86SY0
Accessions	EAW81395 EAW81396 EAW81397 EAW81398 EAW81399 EAW81400 EAW81401 EAW81402 Q8TAM2 AF086168 AK093891 BAG52780 AK124675 BAG54067 AK296077 BAG58833 AK315772 AL833901 CAD38757 AY366523 AAR02192 AY366524 AAR02193 AY373972 AAR19043 BC001563 AAH01563 BC026351 AAH26351 BC095433 AAH95433 BG330023 BU738965 BX161472 CAD61928 BX247959 CAD62299 BX248071 CAD62360 BX248248 CAD62576 BX537546 XM_006720035 XP_006720098 XM_006720037 XP_006720100 XM_011536432 XP_011534734 XM_011536433 XP_011534735 XM_011536434 XP_011534736 XM_011536435 XP_011534737 NM_001288781 NP_001275710 NM_001288782 NP_001275711 NM_001288783 NP_001275712 NM_144596 NP_653197 NM_198309 NP_938051 NM_198310 NP_938052
Function	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Tissue Specificity	Widely expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BBS8 (E-2) - sc-271009 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

BBS8 (C-14) - sc-49806 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

BBS8 (E-20) - sc-49807 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

BBS8 (P-20) - sc-49808 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

BBS8 (H-300) - sc-99095 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-TTC8 antibody - ab57338 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TTC8 antibody - ab173436 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-TTC8 antibody - ab130338 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa316-327) - LS-C112992 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-TTC8 Antibody (aa18-46, AP) - LS-C272695 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa18-46, APC) - LS-C272696 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa18-46, Biotin) - LS-C272698 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa18-46, FITC) - LS-C272699 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa18-46, Azide-free, HRP) - LS-C272700 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa18-46, PE) - LS-C272703 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa17-46) - LS-C326083 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa416-515, Azide-free) - LS-C328874 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-TTC8 Antibody (aa71-120) - LS-C111228 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TTC8 Antibody (aa18-46) - LS-C160305 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

TTC8 Antibody - NBP1-55108 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

TTC8 Antibody - NBP1-88688 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TTC8 Antibody (7E2) - H00123016-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 7E2

TTC8 Antibody - NBP1-49869 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

TTC8 Antibody - H00123016-B01P from Novus Biologicals Prices $349.00 Sizes 50 µg Host Mouse Clonality Polyclonal

TTC8 Antibody - H00123016-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

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