| Gene Symbol |
SPAG5
|
| Entrez Gene |
10615
|
| Alt Symbol |
DEEPEST, MAP126, hMAP126
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sperm associated antigen 5
|
| Other Description |
astrin|mitotic spindle associated protein p126|mitotic spindle coiled-coil related protein|mitotic spindle-associated protein p126|sperm-associated antigen 5
|
| Swissprots |
Q9UFE6 Q96R06 Q9BWE8 O95213 Q9NT17
|
| Accessions |
EAW51106 Q96R06 AF063308 AAD02813 AF345347 AAL06396 AF399910 AAK91712 AK025725 AK292398 BAF85087 AL122116 CAB59275 AL137585 CAB70827 BC000322 AAH00322 BC113055 AAI13056 BI459711 BQ773438 NM_006461 NP_006452
|
| Function |
Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule- kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation- induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU. {ECO:0000269|PubMed:11724960, ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331, ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:21402792, ECO:0000269|Pu
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Note=In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Efficient targeting to the mitotic spindle may depend upon phosphorylation by GSK3B. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (By similarity). In non-mitotic non-stressed cells, shows a microtubuli pattern. In arsenite-stressed cells, accumulates in stress granules. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon. {ECO:0000269|PubMed:11549262}.
|