NUP85

Gene Symbol NUP85
Entrez Gene 79902
Alt Symbol FROUNT, Nup75
Species Human
Gene Type protein-coding
Description nucleoporin 85kDa
Other Description nuclear pore complex protein Nup85|nucleoporin Nup75|nucleoporin Nup85
Swissprots Q9H9U1 B4DPW1 B4DMQ3 Q8NDI4 Q9BW27
Accessions EAW89251 Q9BW27 AF498261 AAM18528 AF514995 AAM76706 AK022611 BAB14130 AK124501 BAG54043 AK295694 BAH12158 AK297574 BAG59965 AK298519 BAG60723 AK302426 BAG63729 AL833893 CAD38749 BC000697 AAH00697 BM973048 DA375719 DA787201 DC424627 XM_005257690 XP_005257747 XM_005257692 XP_005257749 XM_005257693 XP_005257750 XM_006722094 XP_006722157 XM_011525267 XP_011523569 XM_011525268 XP_011523570 XR_243683 XR_429921 XR_934552 NM_001303276 NP_001290205 NM_024844 NP_079120
Function Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2- activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl- inositol 3-kinase-Rac-lammellipodium protrusion cascade. {ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}.
Subcellular Location Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells.
Top Pathways RNA transport

Pericentrin 1 CRISPR/Cas9 KO Plasmid (h) - sc-403161 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 HDR Plasmid (h) - sc-403161-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 Double Nickase Plasmid (h) - sc-403161-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 Double Nickase Plasmid (h2) - sc-403161-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 CRISPR Activation Plasmid (h) - sc-403161-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 CRISPR Activation Plasmid (h2) - sc-403161-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 Lentiviral Activation Particles (h) - sc-403161-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 Lentiviral Activation Particles (h2) - sc-403161-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Pericentrin 1 siRNA (h) - sc-106396 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pericentrin 1 shRNA Plasmid (h) - sc-106396-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Pericentrin 1 shRNA (h) Lentiviral Particles - sc-106396-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nucleoporin NUP85/Pericentrin 1 RNAi - H00079902-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU053541 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15634 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15634 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NUP85 siRNA (Human) - CRJ2655 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NUP85 (NM_024844.3) - SHH356540 from Creative biogene

Category siRNA
Species Reactivities Human

Human NUP85 siRNA - orb273156 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NUP85 shRNA Plasmid (Human) - CHJ2655 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NUP85 miRNA 3'UTR clone - MiUTR1H-06997 from Creative biogene

Species Reactivities Human
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