| Gene Symbol | NUP85 |
|---|---|
| Entrez Gene | 79902 |
| Alt Symbol | FROUNT, Nup75 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nucleoporin 85kDa |
| Other Description | nuclear pore complex protein Nup85|nucleoporin Nup75|nucleoporin Nup85 |
| Swissprots | Q9H9U1 B4DPW1 B4DMQ3 Q8NDI4 Q9BW27 |
| Accessions | EAW89251 Q9BW27 AF498261 AAM18528 AF514995 AAM76706 AK022611 BAB14130 AK124501 BAG54043 AK295694 BAH12158 AK297574 BAG59965 AK298519 BAG60723 AK302426 BAG63729 AL833893 CAD38749 BC000697 AAH00697 BM973048 DA375719 DA787201 DC424627 XM_005257690 XP_005257747 XM_005257692 XP_005257749 XM_005257693 XP_005257750 XM_006722094 XP_006722157 XM_011525267 XP_011523569 XM_011525268 XP_011523570 XR_243683 XR_429921 XR_934552 NM_001303276 NP_001290205 NM_024844 NP_079120 |
| Function | Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2- activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl- inositol 3-kinase-Rac-lammellipodium protrusion cascade. {ECO:0000269|PubMed:12718872, ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:16807356}. |
| Subcellular Location | Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells. |
| Top Pathways | RNA transport |