| Gene Symbol |
MAPT
|
| Entrez Gene |
4137
|
| Alt Symbol |
DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule-associated protein tau
|
| Other Description |
G protein beta1/gamma2 subunit-interacting factor 1|PHF-tau|neurofibrillary tangle protein|paired helical filament-tau|protein phosphatase 1, regulatory subunit 103
|
| Swissprots |
Q9UQ96 Q5XWF0 Q53YB1 P10636 Q1RMF6 P18518 Q9UMH0 Q6QT54 Q5CZI7 Q14799 Q15549 Q15551 Q9UDJ3 Q15550
|
| Accessions |
AAC04277 AAC04278 AAC04279 AGT42007 CBX55119 CCA63951 EAW93565 EAW93566 EAW93567 EAW93568 EAW93569 EAW93570 EAW93571 EAW93572 EAW93573 EAW93574 P10636 AB073354 AF456477 AK055986 BAB71065 AK095802 BAG53132 AK226139 AK299658 BAG61575 AK299704 BAG61605 AW161357 AW295014 AY526356 AAS17881 AY730549 AAU45390 BC000558 AAH00558 BC032572 BC040444 BC061892 BC071830 BC094805 BC098281 AAH98281 BC099721 AAH99721 BC101936 AAI01937 BC114504 AAI14505 BC114948 AAI14949 BI552187 BN000503 CAG26750 BT006772 AAP35418 DN996935 DR002467 FJ429137 ACJ54951 J03778 AAA60615 M25298 AAA57264 X14474 CAA32636 XM_005257362 XP_005257419 XM_005257364 XP_005257421 XM_005257365 XP_005257422 XM_005257366 XP_005257423 XM_005257367 XP_005257424 XM_005257368 XP_005257425 XM_005257369 XP_005257426 XM_005257370 XP_005257427 XM_005257371 XP_005257428 XM_005257372 XP_005257429 XM_005275648 XP_005275705 XM_006725616 XP_006725679 XM_006725617 XP_006725680 XM_006725618 XP_006725681 XM_006725619 XP_006725682 XM_006725620 XP_006725683 XM_006725621 XP_006725684 XM_006725622 XP_006725685 XM_006725623 XP_006725686 XM_006725624 XP_006725687 XM_006725625 XP_006725688 XM_011546345 XP_011544647 XM_011546346 XP_011544648 XM_011546347 XP_011544649 XM_011546348 XP_011544650 XM_011546349 XP_011544651 XM_011546350 XP_011544652 XM_011546351 XP_011544653 XM_011546352 XP_011544654 XM_011546353 XP_011544655 NM_001123066 NP_001116538 NM_001123067 NP_001116539 NM_001203251 NP_001190180 NM_001203252 NP_001190181 NM_005910 NP_005901 NM_016834 NP_058518 NM_016835 NP_058519 NM_016841 NP_058525
|
| Function |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:10747907}. Cell membrane {ECO:0000269|PubMed:10747907}; Peripheral membrane protein {ECO:0000269|PubMed:10747907}; Cytoplasmic side {ECO:0000269|PubMed:10747907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10747907}. Cell projection, axon {ECO:0000269|PubMed:10747907}. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
|
| Tissue Specificity |
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
|
| Top Pathways |
Alzheimer's disease, MAPK signaling pathway
|
