RPA3

Gene Symbol	RPA3
Entrez Gene	6119
Alt Symbol	REPA3
Species	Human
Gene Type	protein-coding
Description	replication protein A3, 14kDa
Other Description	RF-A protein 3|RP-A p14|replication factor A protein 3|replication protein A 14 kDa subunit
Swissprots	Q549U6 P35244
Accessions	AAQ96878 AAX84517 EAL24304 EAW93603 EAW93604 EAW93605 P35244 AK311842 BAG34784 BC005264 AAH05264 BC009868 AAH09868 BT007320 AAP35984 L07493 AAA58350 NM_002947 NP_002938
Function	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in b
Subcellular Location	Nucleus.
Top Pathways	DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RPA14 full length protein - ab40732 from Abcam Category Protein Source E. coli Species Human

RPA14 Recombinant Protein - H00006119-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RPA14 Protein - H00006119-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RPA14 Protein - GTX100088-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Human RPA3 protein - orb245641 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human RPA3 protein - orb245640 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

RPA3 protein (His tag) - 80R-3483 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

RPA3 / RPA14 - H00006119-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RPA3 / RPA14 - H00006119-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RPA3 / RPA14 - H00006119-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPA3 / RPA14 - H00006119-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPA3 fusion protein - ag1065 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Replication protein A 14 kDa subunit - GWB-8CC86D from Genway Biotech Category Protein Prices $185.00, $2,500.00 Sizes 50 µg, 1 mg

Recombinant Human RPA3, His-tagged - RPA3-2982H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human RPA3, His-tagged - RPA3-31128TH from Creative Biomart Category Protein Source E. coli

Recombinant human Replication protein A 14 kDa subunit protein - CSB-EP162394h CSB-BP162394h CSB-MP162394h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Replication protein A 14 kDa subunit - CSB-EP162344h CSB-BP162344h CSB-MP162344h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Replication protein A 14 kDa subunit(RPA3),partial - CSB-RP162394h from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Replication protein A 14 kDa subunit(RPA3),partial - CSB-RP162344h from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Replication protein A 14 kDa subunit(RPA3) - CSB-YP020091HU CSB-EP020091HU CSB-BP020091HU CSB-MP020091HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RPA3 Protein - abx163785 from Abbexa Category Protein Species Human

RPA14 Recombinant Protein Antigen - NBP1-87141PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RPA3-Antibody-N-term-Blocking-Peptide - BP2814a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RPA3 Peptide, Human - M34GP13481H from Creative Peptides Category Peptide Source Synthetic. Species Human

RPA3 Blocking Peptide - CBP7535 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse

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