RPA3

Gene Symbol RPA3
Entrez Gene 6119
Alt Symbol REPA3
Species Human
Gene Type protein-coding
Description replication protein A3, 14kDa
Other Description RF-A protein 3|RP-A p14|replication factor A protein 3|replication protein A 14 kDa subunit
Swissprots Q549U6 P35244
Accessions AAQ96878 AAX84517 EAL24304 EAW93603 EAW93604 EAW93605 P35244 AK311842 BAG34784 BC005264 AAH05264 BC009868 AAH09868 BT007320 AAP35984 L07493 AAA58350 NM_002947 NP_002938
Function As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Plays also a role in b
Subcellular Location Nucleus.
Top Pathways DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

RPA 14 kDa subunit (E-2) - sc-271564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA 14 kDa subunit (E-2): sc-271564. Western blot analysis of RPA 14 kDa subunit expression in K-562 (A) and HL-60 (B) nuclear extracts and K-562 whole cell lysate (C).

RPA 14 kDa subunit (F-12) - sc-46623 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA 14 kDa subunit (F-12): sc-46623. Western blot analysis of human recombinant RPA 14 kDa subunit fusion protein.

RPA 14 kDa subunit (C-16) - sc-30411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA 14 kDa subunit (C-16): sc-30411. Western blot analysis of RPA 14 kDa subunit expression in HL-60 (A) and K-562 (B) whole cell lysates.

RPA 14 kDa subunit (G-20) - sc-46507 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA 14 kDa subunit (G-20): sc-46507. Western blot analysis of RPA 14 kDa subunit expression in NIH/3T3 (A), HL-60 (B) and K-562 (C) whole cell lysates.

RPA 14 kDa subunit (N-15) - sc-30409 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA 14 kDa subunit (N-15): sc-30409. Western blot analysis of RPA 14 kDa subunit expression in HL-60 (A) nuclear extract and K-562 (B) whole cell lysates.

Anti-RPA14 antibody - ab6432 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-RPA14 antibody - ab97436 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RPA14 antibody (ab97436) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLane 3 : MOLT4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-RPA14 antibody - ab58317 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
RPA14 antibody (ab58317) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human prostate.

Anti-RPA14 antibody - ab167593 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-RPA14 antibody (ab167593) at 1 µg/mlLane 1 : RPA14 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-RPA14 antibody [11.1] - ab588 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 11.1
Overlay histogram showing K562 cells stained with ab588 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab588, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-RPA14 antibody - Azide free - ab37679 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-RPA14 antibody - Azide free (ab37679) at 1/2000 dilution + E coli derived fusion proteinSecondaryGoat anti IgY HRP at 1/1000 dilution

Anti-RPA14 antibody - N-terminal - ab80165 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RPA14 antibody - N-terminal (ab80165) at 1/50 dilution + Sk-BR-3 cell line lysate at 35 µg

Anti-RPA3 Antibody (clone 1F4) - LS-C133091 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F4
Western blot of RPA3 expression in transfected 293T cell line by RPA3 monoclonal antibody (M01), clone 1F4.

Anti-RPA3 Antibody (clone 111) IHC-plus™ - LS-B1711 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 111
Anti-RPA3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1711 concentration 5 ug/ml.

Anti-RPA3 Antibody (clone 14.2) - LS-C20047 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 14.2

Anti-RPA3 Antibody (N-Terminus) - LS-C83538 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-RPA3 Antibody (N-Terminus, clone 4H9) - LS-C53373 from LifeSpan Bioscience

Prices $445.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4H9

Anti-RPA3 Antibody - LS-C211480 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPA3 Antibody (HRP) - LS-C211482 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPA3 Antibody (FITC) - LS-C211486 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPA3 Antibody (Biotin) - LS-C211487 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPA3 Antibody - LS-C285756 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPA3 Antibody (HRP) - LS-C317210 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPA3 Antibody (Biotin) - LS-C317213 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPA3 Antibody (FITC) - LS-C318837 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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