RERE
| Gene Symbol | RERE |
|---|---|
| Entrez Gene | 473 |
| Alt Symbol | ARG, ARP, ATN1L, DNB1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | arginine-glutamic acid dipeptide (RE) repeats |
| Other Description | arginine-glutamic acid dipeptide repeats protein|atrophin 2|atrophin-1 like protein|atrophin-1 related protein|atrophin-1-like protein|atrophin-1-related protein |
| Swissprots | O75046 O75359 Q6P6B9 O43393 Q9P2R6 Q9Y2W4 Q5VXL9 |
| Accessions | AAC28264 EAW71598 EAW71599 EAW71600 EAW71601 Q9P2R6 AB007927 BAA32303 AB036737 BAA95898 AF016005 AAC31120 AF118275 AAD27584 AK074834 AK096094 AL050176 BC009619 BC062342 BC167857 AAI67857 CD674939 CD679363 DA868444 XM_005263464 XP_005263521 XM_005263466 XP_005263523 XM_006710653 XP_006710716 XM_011541510 XP_011539812 XM_011541511 XP_011539813 NM_001042681 NP_001036146 NM_001042682 NP_001036147 NM_012102 NP_036234 |
| Function | Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10814707, ECO:0000269|PubMed:11331249}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs. |
| Tissue Specificity | Widely expressed. Expressed in tumor cell lines. {ECO:0000269|PubMed:10729226, ECO:0000269|PubMed:10814707, ECO:0000269|PubMed:11331249}. |
atrophin-2 CRISPR/Cas9 KO Plasmid (h) - sc-404346 from Santa Cruz Biotechnology
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atrophin-2 HDR Plasmid (h) - sc-404346-HDR from Santa Cruz Biotechnology
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atrophin-2 Double Nickase Plasmid (h) - sc-404346-NIC from Santa Cruz Biotechnology
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atrophin-2 Double Nickase Plasmid (h2) - sc-404346-NIC-2 from Santa Cruz Biotechnology
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atrophin-2 CRISPR Activation Plasmid (h) - sc-404346-ACT from Santa Cruz Biotechnology
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atrophin-2 CRISPR Activation Plasmid (h2) - sc-404346-ACT-2 from Santa Cruz Biotechnology
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atrophin-2 Lentiviral Activation Particles (h) - sc-404346-LAC from Santa Cruz Biotechnology
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atrophin-2 Lentiviral Activation Particles (h2) - sc-404346-LAC-2 from Santa Cruz Biotechnology
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atrophin-2 siRNA (h) - sc-88090 from Santa Cruz Biotechnology
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atrophin-2 shRNA Plasmid (h) - sc-88090-SH from Santa Cruz Biotechnology
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atrophin-2 shRNA (h) Lentiviral Particles - sc-88090-V from Santa Cruz Biotechnology
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RERE RNAi - H00000473-R01 from Novus Biologicals
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MISSION® esiRNA - EHU082401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18148 from Sigma-Aldrich
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RERE siRNA (Human) - CRH0329 from Cohesion Biosciences
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RERE - MBS8209594 from MyBioSource
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shRNA set against Human RERE (NM_012102.3) - SHH391984 from Creative biogene
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shRNA set against Human RERE(NM_001042682.1) - SHR176190 from Creative biogene
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shRNA set against Human RERE(NM_001042681.1) - SHR176226 from Creative biogene
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Human RERE siRNA - orb260831 from Biorbyt
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RERE shRNA Plasmid (Human) - CHH0329 from Cohesion Biosciences
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RERE miRNA 3'UTR clone - MiUTR1H-08739 from Creative biogene
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RERE miRNA 3'UTR clone - MiUTR1H-08740 from Creative biogene
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