| Gene Symbol |
RERE
|
| Entrez Gene |
473
|
| Alt Symbol |
ARG, ARP, ATN1L, DNB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
arginine-glutamic acid dipeptide (RE) repeats
|
| Other Description |
arginine-glutamic acid dipeptide repeats protein|atrophin 2|atrophin-1 like protein|atrophin-1 related protein|atrophin-1-like protein|atrophin-1-related protein
|
| Swissprots |
O75046 O75359 Q6P6B9 O43393 Q9P2R6 Q9Y2W4 Q5VXL9
|
| Accessions |
AAC28264 EAW71598 EAW71599 EAW71600 EAW71601 Q9P2R6 AB007927 BAA32303 AB036737 BAA95898 AF016005 AAC31120 AF118275 AAD27584 AK074834 AK096094 AL050176 BC009619 BC062342 BC167857 AAI67857 CD674939 CD679363 DA868444 XM_005263464 XP_005263521 XM_005263466 XP_005263523 XM_006710653 XP_006710716 XM_011541510 XP_011539812 XM_011541511 XP_011539813 NM_001042681 NP_001036146 NM_001042682 NP_001036147 NM_012102 NP_036234
|
| Function |
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. {ECO:0000269|PubMed:11331249}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:10814707, ECO:0000269|PubMed:11331249}. Note=Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
|
| Tissue Specificity |
Widely expressed. Expressed in tumor cell lines. {ECO:0000269|PubMed:10729226, ECO:0000269|PubMed:10814707, ECO:0000269|PubMed:11331249}.
|