Gene Symbol | Tyrobp |
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Entrez Gene | 22177 |
Alt Symbol | DAP12, KARAP, Ly83 |
Species | Mouse |
Gene Type | protein-coding |
Description | TYRO protein tyrosine kinase binding protein |
Other Description | DNAX-activation protein 12|KAR-associated protein|TYRO protein tyrosine kinase-binding protein|killer cell activating receptor associated protein|killer-activating receptor-associated protein |
Swissprots | O54885 O88603 |
Accessions | EDL24026 EDL24027 O54885 AF024637 AAD09438 AF077829 AAC95529 AK154480 BAE32616 BC056450 AAH56450 NM_011662 NP_035792 |
Function | Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. {ECO:0000269|PubMed:17086186}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Natural killer cell mediated cytotoxicity, Osteoclast differentiation |
DAP12 CRISPR/Cas9 KO Plasmid (m) - sc-423568 from Santa Cruz Biotechnology
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DAP12 HDR Plasmid (m) - sc-423568-HDR from Santa Cruz Biotechnology
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DAP12 Double Nickase Plasmid (m) - sc-423568-NIC from Santa Cruz Biotechnology
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DAP12 Double Nickase Plasmid (m2) - sc-423568-NIC-2 from Santa Cruz Biotechnology
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DAP12 CRISPR Activation Plasmid (m) - sc-423568-ACT from Santa Cruz Biotechnology
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DAP12 CRISPR Activation Plasmid (m2) - sc-423568-ACT-2 from Santa Cruz Biotechnology
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DAP12 Lentiviral Activation Particles (m) - sc-423568-LAC from Santa Cruz Biotechnology
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DAP12 Lentiviral Activation Particles (m2) - sc-423568-LAC-2 from Santa Cruz Biotechnology
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DAP12 siRNA (m) - sc-42854 from Santa Cruz Biotechnology
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DAP12 shRNA Plasmid (m) - sc-42854-SH from Santa Cruz Biotechnology
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DAP12 shRNA (m) Lentiviral Particles - sc-42854-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN43767 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43767 from Sigma-Aldrich
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TYROBP siRNA (Mouse) - CRM4300 from Cohesion Biosciences
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TYROBP - MBS8200010 from MyBioSource
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DAP12 CRISPR/Cas9 KO Plasmid (m2) - sc-423568-KO-2 from Santa Cruz Biotechnology
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DAP12 HDR Plasmid (m2) - sc-423568-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Mouse TYROBP (NM_011662.2) - SHH438472 from Creative biogene
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shRNA set against Mouse Tyrobp(NM_011662.2) - SHL108882 from Creative biogene
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TYROBP shRNA Plasmid (Mouse) - CHM4300 from Cohesion Biosciences
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TYROBP miRNA 3'UTR clone - MiUTR1M-12359 from Creative biogene
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