| Gene Symbol |
Tyrobp
|
| Entrez Gene |
22177
|
| Alt Symbol |
DAP12, KARAP, Ly83
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TYRO protein tyrosine kinase binding protein
|
| Other Description |
DNAX-activation protein 12|KAR-associated protein|TYRO protein tyrosine kinase-binding protein|killer cell activating receptor associated protein|killer-activating receptor-associated protein
|
| Swissprots |
O54885 O88603
|
| Accessions |
EDL24026 EDL24027 O54885 AF024637 AAD09438 AF077829 AAC95529 AK154480 BAE32616 BC056450 AAH56450 NM_011662 NP_035792
|
| Function |
Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. {ECO:0000269|PubMed:17086186}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity, Osteoclast differentiation
|