Gene Symbol | HIST2H2BE |
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Entrez Gene | 8349 |
Alt Symbol | GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 2, H2be |
Other Description | H2B histone family, member Q|histone 2, H2be|histone H2B type 2-E|histone H2B-GL105|histone H2B.q |
Swissprots | Q16778 Q4KMY1 A8K110 Q9UE88 Q5QNX0 A3KMC7 |
Accessions | AAN59961 CAA41051 CAI12568 EAW53605 Q16778 AK093747 AK289725 BAF82414 BC005827 AAH05827 BC069193 AAH69193 BC096121 AAH96121 BC098112 AAH98112 BC098289 AAH98289 BC107084 AAI07085 BC107085 AAI07086 CR541895 CAG46693 HQ447538 ADQ32024 M60756 AAA63192 NM_003528 NP_003519 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |
Histone cluster 2 H2BE CRISPR/Cas9 KO Plasmid (h) - sc-411151 from Santa Cruz Biotechnology
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Histone cluster 2 H2BE HDR Plasmid (h) - sc-411151-HDR from Santa Cruz Biotechnology
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Histone cluster 2 H2BE Double Nickase Plasmid (h) - sc-411151-NIC from Santa Cruz Biotechnology
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Histone cluster 2 H2BE Double Nickase Plasmid (h2) - sc-411151-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2BE CRISPR Activation Plasmid (h) - sc-411151-ACT from Santa Cruz Biotechnology
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Histone cluster 2 H2BE CRISPR Activation Plasmid (h2) - sc-411151-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2BE Lentiviral Activation Particles (h) - sc-411151-LAC from Santa Cruz Biotechnology
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Histone cluster 2 H2BE Lentiviral Activation Particles (h2) - sc-411151-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H2BE siRNA (h) - sc-105510 from Santa Cruz Biotechnology
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Histone cluster 2 H2BE shRNA Plasmid (h) - sc-105510-SH from Santa Cruz Biotechnology
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Histone cluster 2 H2BE shRNA (h) Lentiviral Particles - sc-105510-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU117811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10111 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13191 from Sigma-Aldrich
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HIST2H2BE siRNA (Human) - CRH5469 from Cohesion Biosciences
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HIST2H2BE - MBS8203263 from MyBioSource
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shRNA set against Human HIST2H2BE(NM_003528.2) - SHH123635 from Creative biogene
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Human HIST2H2BE siRNA - orb265971 from Biorbyt
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HIST2H2BE shRNA Plasmid (Human) - CHH5469 from Cohesion Biosciences
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HIST2H2BE miRNA 3'UTR clone - MiUTR1H-04567 from Creative biogene
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