| Gene Symbol |
LRRC4C
|
| Entrez Gene |
57689
|
| Alt Symbol |
NGL-1, NGL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 4C
|
| Other Description |
leucine-rich repeat-containing protein 4C|netrin-G1 ligand
|
| Swissprots |
Q7L0N3 A8K0T1 Q9HCJ2
|
| Accessions |
EAW68107 Q9HCJ2 AB046800 BAB13406 AI806109 AK289646 BAF82335 AY358293 AAQ88660 BC041374 AAH41374 BX951676 DA387604 DQ084201 AAY86708 DQ084202 AAY86709 XM_011520238 XP_011518540 XM_011520239 XP_011518541 XM_011520240 XP_011518542 XM_011520241 XP_011518543 XM_011520242 XP_011518544 XM_011520243 XP_011518545 XM_011520244 XP_011518546 XM_011520245 XP_011518547 NM_001258419 NP_001245348 NM_020929 NP_065980 NR_047673 NR_047674
|
| Function |
May promote neurite outgrowth of developing thalamic neurons. {ECO:0000269|PubMed:14595443}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}.
|
| Tissue Specificity |
Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression. {ECO:0000269|PubMed:14595443}.
|
| Top Pathways |
Axon guidance, Cell adhesion molecules (CAMs)
|
![Western Blot: Netrin G1 ligand Overexpression Lysate (Adult Normal) [NBP2-06594] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Netrin G1 ligand.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4756_Netrin%2520G1%2520ligand%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06594-img0001.jpg)