BCO1

Gene Symbol BCO1
Entrez Gene 53630
Alt Symbol BCDO, BCDO1, BCMO, BCMO1, BCO
Species Human
Gene Type protein-coding
Description beta-carotene oxygenase 1
Other Description beta,beta-carotene 15,15'-monooxygenase|beta-carotene 15, 15'-dioxygenase 1|beta-carotene 15,15'-monooxygenase 1|beta-carotene dioxygenase 1
Swissprots A0AV48 Q9HAY6 Q9NVH5 A0AV50
Accessions EAW95537 EAW95538 Q9HAY6 AF294900 AAG15380 AK001592 BAA91776 AK296011 BAG58782 BC022269 BC126210 AAI26211 BC126212 AAI26213 HQ258298 ADR83052 XM_011523109 XP_011521411 XM_011523110 XP_011521412 NM_017429 NP_059125
Function Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
Tissue Specificity Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. {ECO:0000269|PubMed:11401432}.
Top Pathways Retinol metabolism

BCMO1 CRISPR/Cas9 KO Plasmid (h) - sc-405374 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 HDR Plasmid (h) - sc-405374-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 Double Nickase Plasmid (h) - sc-405374-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 Double Nickase Plasmid (h2) - sc-405374-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 CRISPR Activation Plasmid (h) - sc-405374-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 CRISPR Activation Plasmid (h2) - sc-405374-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 Lentiviral Activation Particles (h) - sc-405374-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 Lentiviral Activation Particles (h2) - sc-405374-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BCMO1 siRNA (h) - sc-93190 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BCMO1 shRNA Plasmid (h) - sc-93190-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BCMO1 shRNA (h) Lentiviral Particles - sc-93190-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU011061 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3926 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3926 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05301 from Sigma-Aldrich

Category miRNA

BCMO1 siRNA (Human) - CRH9976 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCMO1 RNAi - H00053630-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BCMO1 - MBS8228358 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BCMO1 (NM_017429.2) - SHH246110 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human BCMO1(NM_017429.2) - SHG098377 from Creative biogene

Category siRNA
Species Reactivities Human

Human BCMO1 siRNA - orb270478 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BCMO1 shRNA Plasmid (Human) - CHH9976 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BCMO1 miRNA 3'UTR clone - MiUTR1H-00858 from Creative biogene

Species Reactivities Human
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