BCO1

Gene Symbol BCO1
Entrez Gene 53630
Alt Symbol BCDO, BCDO1, BCMO, BCMO1, BCO
Species Human
Gene Type protein-coding
Description beta-carotene oxygenase 1
Other Description beta,beta-carotene 15,15'-monooxygenase|beta-carotene 15, 15'-dioxygenase 1|beta-carotene 15,15'-monooxygenase 1|beta-carotene dioxygenase 1
Swissprots A0AV48 Q9HAY6 Q9NVH5 A0AV50
Accessions EAW95537 EAW95538 Q9HAY6 AF294900 AAG15380 AK001592 BAA91776 AK296011 BAG58782 BC022269 BC126210 AAI26211 BC126212 AAI26213 HQ258298 ADR83052 XM_011523109 XP_011521411 XM_011523110 XP_011521412 NM_017429 NP_059125
Function Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
Tissue Specificity Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. {ECO:0000269|PubMed:11401432}.
Top Pathways Retinol metabolism

BCMO1 (K-14) - sc-163736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BCMO1 (K-14): sc-163736. Western blot analysis of BCMO1 expression in Jurkat whole cell lysate.

BCMO1 (S-13) - sc-163737 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BCMO1 (S-13): sc-163737. Western blot analysis of BCMO1 expression in WiDR whole cell lysate.

Anti-BCMO1 antibody - ab199272 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-BCMO1 antibody (ab199272) at 1/500 dilution + Human liver tissue lysate

Anti-BCMO1 antibody - ab107418 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-BCMO1 antibody (ab107418) at 1/100 dilution + WiDr cell line lysates at 35 µg

Anti-BCMO1 antibody - ab128370 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (aa263-292, AP) - LS-C233103 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (aa263-292, APC) - LS-C233105 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (aa263-292, Biotin) - LS-C233106 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (aa263-292, FITC) - LS-C233107 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (aa263-292, PE) - LS-C233108 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (aa263-292, Azide-free, HRP) - LS-C249512 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (aa270-300) - LS-C319816 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCO1 / BCMO1 Antibody (C-Terminus) - LS-C151634 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BCMO1 antibody Western Blot of A549 cell lysates. Antibody Dilution: 1.0 ug/ml. BCMO1 is supported by BioGPS gene expression data to be expressed in A549. Antibody dilution: 1 ug/ml.

Anti-BCO1 / BCMO1 Antibody (N-Terminus) - LS-C346044 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of BCMO1 Antibody with human 721_B Whole Cell lysate.

Anti-BCO1 / BCMO1 Antibody (aa263-292) - LS-C156780 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
BCMO1 Antibody western blot of WiDr cell line lysates (35 ug/lane). The BCMO1 antibody detected the BCMO1 protein (arrow).

Anti-BCO1 / BCMO1 Antibody (aa189-238) - LS-C151635 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BCMO1 antibody Western Blot of 293T lysate. Antibody Dilution: 1.0 ug/ml. BCMO1 is supported by BioGPS gene expression data to be expressed in HEK293T. Antibody dilution: 1 ug/ml.

BCMO1 Antibody - NBP1-91698 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: BCMO1 Antibody [NBP1-91698] - Staining of human cell line A-431 shows positivity in centrosome.

Anti-BCMO1 antibody produced in rabbit - HPA043811 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BCMO1: <B>Cat. No. HPA043811</B>: Immunohistochemical staining of human rectum shows strong membranous positivity in glandular cells.

ANTI-BCMO1 (CENTER) antibody produced in rabbit - SAB1302441 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-BCMO1 (Center): <B>Cat. No. SAB1302441 </B>: BCMO1 Antibody (Center) western blot analysis in WiDr cell line lysates (35 μg/lane).

Anti-BCMO1 (406-420) antibody produced in rabbit - SAB1104305 from Sigma-Aldrich

Prices $285.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human BCMO1 was separated on SDS-PAGE, blotted with Anti-BCMO1 (406-420) (<B>Cat. No. SAB1104305</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:250

Anti-BCMO1 antibody produced in rabbit - SAB2107829 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-BCMO1: <B>Cat. No. SAB2107829</B>: Western blot analysis of BCMO1 with BCMO1 (beta-carotene 15,15′-monooxygenase 1) antibody against the middle region of BCMO1 (50 μg) antibody at 1.0 μg/mL.

BCMO1 antibody - C-terminal region (ARP64136_P050) - ARP64136_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BCMO1 antibody - middle region (ARP64137_P050) - ARP64137_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BCMO1 Antibody - N-terminal region (ARP74413_P050) - ARP74413_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

BCMO1 Antibody - middle region (OAAB00485) - OAAB00485 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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