| Gene Symbol |
BECN1
|
| Entrez Gene |
527278
|
| Alt Symbol |
ATG6
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
beclin 1, autophagy related
|
| Other Description |
beclin-1|coiled-coil myosin-like BCL2-interacting protein
|
| Swissprots |
Q4A1L4
|
| Accessions |
DAA18463 Q4A1L4 AM051355 CAJ19744 BC102177 AAI02178 XM_010816250 XP_010814552 NM_001033627 NP_001028799
|
| Function |
Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense (By similarity). {ECO:0000250|UniProtKB:Q14457}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:O88597}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells. {ECO:0000250|UniProtKB:O88597, ECO:0000250|UniProtKB:Q14457}.
|
| Top Pathways |
Regulation of autophagy
|