Gene Symbol | C1QC |
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Entrez Gene | 714 |
Alt Symbol | C1Q-C, C1QG |
Species | Human |
Gene Type | protein-coding |
Description | complement component 1, q subcomponent, C chain |
Other Description | complement C1q subcomponent subunit C|complement component 1, q subcomponent, gamma polypeptide |
Swissprots | Q96H05 Q7Z502 P02747 Q96DL2 |
Accessions | EAW95016 EAW95017 EAW95018 P02747 AF087892 AAP97191 AK057792 BAB71575 AK130613 AK226152 AM392881 CAL37759 AM393232 CAL38110 AM393519 CAL38396 BC009016 AAH09016 BG060138 CB995661 DA849505 NM_001114101 NP_001107573 NM_172369 NP_758957 |
Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
Subcellular Location | Secreted. |
Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Chagas disease (American trypanosomiasis), Staphylococcus aureus infection |
C1q-C CRISPR/Cas9 KO Plasmid (h) - sc-403618 from Santa Cruz Biotechnology
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C1q-C HDR Plasmid (h) - sc-403618-HDR from Santa Cruz Biotechnology
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C1q-C Double Nickase Plasmid (h) - sc-403618-NIC from Santa Cruz Biotechnology
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C1q-C Double Nickase Plasmid (h2) - sc-403618-NIC-2 from Santa Cruz Biotechnology
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C1q-C CRISPR Activation Plasmid (h) - sc-403618-ACT from Santa Cruz Biotechnology
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C1q-C CRISPR Activation Plasmid (h2) - sc-403618-ACT-2 from Santa Cruz Biotechnology
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C1q-C Lentiviral Activation Particles (h) - sc-403618-LAC from Santa Cruz Biotechnology
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C1q-C Lentiviral Activation Particles (h2) - sc-403618-LAC-2 from Santa Cruz Biotechnology
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C1q-C siRNA (h) - sc-72202 from Santa Cruz Biotechnology
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C1q-C shRNA Plasmid (h) - sc-72202-SH from Santa Cruz Biotechnology
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C1q-C shRNA (h) Lentiviral Particles - sc-72202-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU150221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4685 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4685 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12006 from Sigma-Aldrich
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C1QC siRNA (Human) - CRH0493 from Cohesion Biosciences
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C1QC - MBS8206175 from MyBioSource
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shRNA set against Human C1QC (NM_172369.3) - SHH250709 from Creative biogene
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shRNA set against Human C1QC(NM_172369.3) - SHG120655 from Creative biogene
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Human C1QC siRNA - orb260995 from Biorbyt
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C1QC shRNA Plasmid (Human) - CHH0493 from Cohesion Biosciences
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C1QC miRNA 3'UTR clone - MiUTR1H-01285 from Creative biogene
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C1QC miRNA 3'UTR clone - MiUTR3H-00507 from Creative biogene
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