COPB1

Gene Symbol COPB1
Entrez Gene 1315
Alt Symbol COPB
Species Human
Gene Type protein-coding
Description coatomer protein complex, subunit beta 1
Other Description beta coat protein|beta-coat protein|beta-cop|coatomer subunit beta
Swissprots Q9NTK2 P53618 Q6GTT7 Q9UNW7 D3DQX0
Accessions EAW68481 EAW68482 EAW68483 EAW68484 EAW68485 P53618 AA443270 AF084457 AAD41240 AF111807 AAL39009 AK001203 AK128844 AL136593 CAB66528 AM393381 CAL38259 BC012572 BC037280 AAH37280 DA725605 DB455108 DQ892479 ABM83405 DQ895690 ABM86616 X82103 CAA57622 NM_001144061 NP_001137533 NM_001144062 NP_001137534 NM_016451 NP_057535
Function The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa- type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipi
Subcellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Endoplasmic reticulum- Golgi intermediate compartment. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (By similarity). Found in perinuclear vesicular-tubular clusters (VTCs) and in the Golgi region where associated with vesicles, buds and rims of the Golgi stack (By similarity). Occasionally present at the trans-side of Golgi, but mainly present at the cis- Golgi side in transitional areas (TA), on so-called peripheral elements (PE) consisting of tubules and vesicles located between the cup-shaped transitional elements (TE) of the rough endoplasmic reticulum (RER) and the cis-most Golgi cisternae (By similarity). Present in cy

COPB (C-11) - sc-137226 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPB (C-11): sc-137226. Western blot analysis of COPB expression in non-transfected: sc-117752 (A) and mouse COPB transfected: sc-126656 (B) 293T whole cell lysates.

COPB (D-9) - sc-165975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPB (D-9): sc-165975. Western blot analysis of COPB expression in non-transfected: sc-117752 (A) and mouse COPB transfected: sc-126656 (B) 293T whole cell lysates.

COPB (D-10) - sc-393615 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPB (D-10): sc-393615. Western blot analysis of COPB expression in C6 (A) and Hep G2 (B) whole cell lysates.

COPB (E-2) - sc-165976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPB (E-2): sc-165976. Western blot analysis of COPB expression in non-transfected: sc-117752 (A) and mouse COPB transfected: sc-126656 (B) 293T whole cell lysates.

COPB (H-300) - sc-30091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
COPB (H-300): sc-30091. Western blot analysis of COPB expression in non-transfected: sc-117752 (A) and mouse COPB transfected: sc-126656 (B) 293T whole cell lysates.

COPB (T-14) - sc-13335 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
COPB (T-14): sc-13335. Western blot analysis of COPB expression in non-transfected: sc-117752 (A) and mouse COPB transfected: sc-126656 (B) 293T whole cell lysates.

COPB (Y-20) - sc-13337 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-beta COP antibody [maD] - ab6323 from Abcam

Prices $398.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone maD
Anti-beta COP antibody [maD] (ab6323) at 1/2000 dilution + A549 whole cell lysate at 40 µgSecondaryHRP-conjugated donkey anti-mouse IgG at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Observed band size : 95 kDa (why is the actual band size different from the predicted?)Exposure time : 25 secondsThis image is courtesy of an Abreview submitted by Armen PertosyanSee Abreview

Anti-COPB1 / Beta-COP Antibody - LS-C109495 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence of methanol-fixed HeLa, using COPB antibody at 1:100 dilution.

Anti-COPB1 / Beta-COP Antibody - LS-C14584 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COPB1 / Beta-COP Antibody (aa496-513) - LS-C14588 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (aa701-715) - LS-C79755 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-COPB1 / Beta-COP Antibody (aa350-380, AP) - LS-C221854 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (aa350-380, APC) - LS-C221855 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (aa350-380, FITC) - LS-C221857 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (aa350-380, Biotin) - LS-C221856 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (aa350-380, PE) - LS-C221859 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (aa350-380) - LS-C320520 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (aa350-380, Azide-free, HRP) - LS-C221858 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPB1 / Beta-COP Antibody (clone 3E10) - LS-C196951 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3E10
Detection limit for recombinant GST tagged COPB is approximately 0.3 ng/ml as a capture antibody.

Anti-COPB1 / Beta-COP Antibody (aa342-391) - LS-C81716 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Fetal liver cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6%-18%.

Anti-COPB1 / Beta-COP Antibody (aa350-380) - LS-C166941 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPB1 Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The COPB1 antibody detected the COPB1 protein (arrow).

beta COP Antibody - NBP2-39027 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: beta COP Antibody [NBP2-39027] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

beta COP Antibody - NBP2-15579 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: beta COP Antibody [NBP2-15579] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE gel, diluted at 1:1000.

beta COP Antibody - NBP2-15578 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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