NFE2
| Gene Symbol | NFE2 |
|---|---|
| Entrez Gene | 4778 |
| Alt Symbol | NF-E2, p45 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear factor, erythroid 2 |
| Other Description | leucine zipper protein NF-E2|nuclear factor (erythroid-derived 2), 45kD|nuclear factor (erythroid-derived 2), 45kDa|nuclear factor, erythroid-derived 2 45 kDa subunit|p45 NF-E2|transcription factor NF-E2 45 kDa subunit |
| Swissprots | Q6ICV9 Q16621 Q07720 |
| Accessions | ABC79302 CCQ43105 CCQ77681 EAW96771 EAW96772 EAW96773 Q16621 AK290555 BAF83244 AK290564 BAF83253 AK313207 BAG36023 BC005044 AAH05044 BE243330 BT007288 AAP35952 BX406317 CR450284 CAG29280 DQ893437 ABM84363 DQ896796 ABM87795 EU176417 ABW03868 GD141614 GU068583 ACY92458 L13974 AAA35612 L24122 AAA16118 S77763 AAB34115 XM_005268906 XP_005268963 XM_011538397 XP_011536699 NM_001136023 NP_001129495 NM_001261461 NP_001248390 NM_006163 NP_006154 |
| Function | Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron. {ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:16287851}. |
| Subcellular Location | Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH. |
| Tissue Specificity | Expressed in hematopoietic cells and also in colon and testis. |
NF-E2 CRISPR/Cas9 KO Plasmid (h) - sc-401788 from Santa Cruz Biotechnology
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NF-E2 HDR Plasmid (h) - sc-401788-HDR from Santa Cruz Biotechnology
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NF-E2 Double Nickase Plasmid (h) - sc-401788-NIC from Santa Cruz Biotechnology
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NF-E2 Double Nickase Plasmid (h2) - sc-401788-NIC-2 from Santa Cruz Biotechnology
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NF-E2 CRISPR Activation Plasmid (h) - sc-401788-ACT from Santa Cruz Biotechnology
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NF-E2 CRISPR Activation Plasmid (h2) - sc-401788-ACT-2 from Santa Cruz Biotechnology
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NF-E2 Lentiviral Activation Particles (h) - sc-401788-LAC from Santa Cruz Biotechnology
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NF-E2 Lentiviral Activation Particles (h2) - sc-401788-LAC-2 from Santa Cruz Biotechnology
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NF-E2 siRNA (h) - sc-36046 from Santa Cruz Biotechnology
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NF-E2 shRNA Plasmid (h) - sc-36046-SH from Santa Cruz Biotechnology
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NF-E2 shRNA (h) Lentiviral Particles - sc-36046-V from Santa Cruz Biotechnology
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Nuclear Factor Erythroid Derived 2 RNAi - H00004778-R01 from Novus Biologicals
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MISSION® esiRNA - EHU156661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15243 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15243 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02367 from Sigma-Aldrich
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NFE2 siRNA (Human) - CRH3170 from Cohesion Biosciences
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NF-E2 CRISPR/Cas9 KO Plasmid (h2) - sc-401788-KO-2 from Santa Cruz Biotechnology
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NF-E2 HDR Plasmid (h2) - sc-401788-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NFE2 (NM_006163.2) - SHH351764 from Creative biogene
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Human NFE2 siRNA - orb263672 from Biorbyt
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NFE2 shRNA Plasmid (Human) - CHH3170 from Cohesion Biosciences
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NFE2 miRNA 3'UTR clone - MiUTR3H-04157 from Creative biogene
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NFE2 miRNA 3'UTR clone - MiUTR3H-04158 from Creative biogene
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