Gene Symbol | SELE |
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Entrez Gene | 6401 |
Alt Symbol | CD62E, ELAM, ELAM1, ESEL, LECAM2 |
Species | Human |
Gene Type | protein-coding |
Description | selectin E |
Other Description | CD62 antigen-like family member E|E-selectin|ELAM-1|endothelial adhesion molecule 1|endothelial leukocyte adhesion molecule 1|leukocyte endothelial cell adhesion molecule 2|leukocyte-endothelial cell adhesion molecule 2 |
Swissprots | P16111 A2RRD6 P16581 |
Accessions | AAA52375 AAN01237 EAW90860 P16581 AK314214 BAG36888 AY367062 AAQ67702 BC131551 AAI31552 BC142677 AAI42678 BC142711 AAI42712 DB209354 M24736 AAA52376 M30640 AAA52377 NM_000450 NP_000441 |
Function | Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Top Pathways | Cell adhesion molecules (CAMs), Malaria, African trypanosomiasis, TNF signaling pathway |
E-Selectin CRISPR/Cas9 KO Plasmid (h) - sc-400452 from Santa Cruz Biotechnology
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E-Selectin HDR Plasmid (h) - sc-400452-HDR from Santa Cruz Biotechnology
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E-Selectin Double Nickase Plasmid (h) - sc-400452-NIC from Santa Cruz Biotechnology
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E-Selectin Double Nickase Plasmid (h2) - sc-400452-NIC-2 from Santa Cruz Biotechnology
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E-Selectin CRISPR Activation Plasmid (h) - sc-400452-ACT from Santa Cruz Biotechnology
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E-Selectin CRISPR Activation Plasmid (h2) - sc-400452-ACT-2 from Santa Cruz Biotechnology
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E-Selectin Lentiviral Activation Particles (h) - sc-400452-LAC from Santa Cruz Biotechnology
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E-Selectin Lentiviral Activation Particles (h2) - sc-400452-LAC-2 from Santa Cruz Biotechnology
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E-Selectin siRNA (h) - sc-29296 from Santa Cruz Biotechnology
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E-Selectin shRNA Plasmid (h) - sc-29296-SH from Santa Cruz Biotechnology
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E-Selectin shRNA (h) Lentiviral Particles - sc-29296-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU025421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19052 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19052 from Sigma-Aldrich
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SELE siRNA (Human) - CRH4324 from Cohesion Biosciences
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SELE - MBS8201942 from MyBioSource
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shRNA set against Human SELE (NM_000450.2) - SHH404052 from Creative biogene
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E-Selectin CRISPR/Cas9 KO Plasmid (h2) - sc-400452-KO-2 from Santa Cruz Biotechnology
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E-Selectin HDR Plasmid (h2) - sc-400452-HDR-2 from Santa Cruz Biotechnology
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Human SELE siRNA - orb264826 from Biorbyt
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SELE shRNA Plasmid (Human) - CHH4324 from Cohesion Biosciences
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SELE miRNA 3'UTR clone - MiUTR3H-00724 from Creative biogene
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