Gene Symbol | SPCS3 |
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Entrez Gene | 60559 |
Alt Symbol | PRO3567, SPC22/23, SPC3, YLR066W |
Species | Human |
Gene Type | protein-coding |
Description | signal peptidase complex subunit 3 homolog (S. cerevisiae) |
Other Description | SPase 22 kDa subunit|SPase 22/23 kDa subunit|microsomal signal peptidase 22/23 kDa subunit|microsomal signal peptidase 23 kDa subunit|signal peptidase complex subunit 3 |
Swissprots | P61009 |
Accessions | CAH05566 EAX04718 EAX04719 P61009 AK026302 BAB15437 AK092634 AL136660 CAB66595 AY359044 AAQ89403 BC043490 BC047290 AAH47290 BC053883 DB285025 EU831652 ACE87252 EU831735 ACE86569 HQ448610 ADQ33088 NM_021928 NP_068747 |
Function | Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}. |
Subcellular Location | Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Protein export |
SPCS3 CRISPR/Cas9 KO Plasmid (h) - sc-410609 from Santa Cruz Biotechnology
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SPCS3 HDR Plasmid (h) - sc-410609-HDR from Santa Cruz Biotechnology
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SPCS3 Double Nickase Plasmid (h) - sc-410609-NIC from Santa Cruz Biotechnology
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SPCS3 Double Nickase Plasmid (h2) - sc-410609-NIC-2 from Santa Cruz Biotechnology
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SPCS3 CRISPR Activation Plasmid (h) - sc-410609-ACT from Santa Cruz Biotechnology
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SPCS3 CRISPR Activation Plasmid (h2) - sc-410609-ACT-2 from Santa Cruz Biotechnology
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SPCS3 Lentiviral Activation Particles (h) - sc-410609-LAC from Santa Cruz Biotechnology
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SPCS3 Lentiviral Activation Particles (h2) - sc-410609-LAC-2 from Santa Cruz Biotechnology
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SPCS3 siRNA (h) - sc-89051 from Santa Cruz Biotechnology
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SPCS3 shRNA Plasmid (h) - sc-89051-SH from Santa Cruz Biotechnology
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SPCS3 shRNA (h) Lentiviral Particles - sc-89051-V from Santa Cruz Biotechnology
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SPCS3 RNAi - H00060559-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20439 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20439 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06911 from Sigma-Aldrich
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SPCS3 siRNA (Human) - CRJ1816 from Cohesion Biosciences
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SPCS3 - MBS8223366 from MyBioSource
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shRNA set against Human SPCS3 (NM_021928.3) - SHH416340 from Creative biogene
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Human SPCS3 siRNA - orb272317 from Biorbyt
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SPCS3 shRNA Plasmid (Human) - CHJ1816 from Cohesion Biosciences
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SPCS3 miRNA 3'UTR clone - MiUTR4H-TG08466 from Creative biogene
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