| Gene Symbol | TRPC4 |
|---|---|
| Entrez Gene | 7223 |
| Alt Symbol | HTRP-4, HTRP4, TRP4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transient receptor potential cation channel, subfamily C, member 4 |
| Other Description | short transient receptor potential channel 4|trp-related protein 4 |
| Swissprots | Q9UIB2 Q9UBN4 B1ALE1 B1ALE0 Q9UIB1 Q96P03 B1ALE2 Q9UIB0 Q15721 Q96P04 Q96P05 Q3SWS6 |
| Accessions | EAX08595 EAX08596 EAX08597 EAX08598 EAX08599 EAX08600 EAX08601 Q9UBN4 AF063822 AAF22927 AF063823 AAF22928 AF063824 AAF22929 AF063825 AAF22930 AF175406 AAD51736 AF421358 AAL24549 AF421359 AAL24550 AF421360 AAL24551 AF421361 AAL24552 AF421362 AAL24553 AK312524 BAG35423 BC104725 AAI04726 BC105306 AAI05307 BC105641 AAI05642 BC105917 AAI05918 BX648312 CN364204 DB258184 DB278337 DB308366 U40983 AAC50630 XM_011535206 XP_011533508 XM_011535207 XP_011533509 NM_001135955 NP_001129427 NM_001135956 NP_001129428 NM_001135957 NP_001129429 NM_001135958 NP_001129430 NM_003306 NP_003297 NM_016179 NP_057263 |
| Function | Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. {ECO:0000269|PubMed:16144838, ECO:0000269|PubMed:19996314}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor. |
| Tissue Specificity | Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. {ECO:0000269|PubMed:19996314}. |