Gene Symbol | GAREM |
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Entrez Gene | 64762 |
Alt Symbol | C18orf11, FAM59A, Gm944 |
Species | Human |
Gene Type | protein-coding |
Description | GRB2 associated, regulator of MAPK1 |
Other Description | GRB2-associated and regulator of MAPK protein|GRB2-associated and regulator of MAPK1|Grb2-associated and regulator of Erk/MAPK|family with sequence similarity 59, member A|protein FAM59A |
Swissprots | Q8ND03 Q9H706 Q0VAG3 Q0VAG4 Q9BSF5 |
Accessions | EAX01286 EAX01287 Q9H706 AF086529 AI479499 AK025263 BAB15094 AK025660 AK297430 BAG59858 AL834491 CAD39149 BC005074 AAH05074 BC121067 AAI21068 BC121068 AAI21069 XM_011526139 XP_011524441 XM_011526140 XP_011524442 NM_001242409 NP_001229338 NM_022751 NP_073588 |
Function | Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:19509291}. |
Tissue Specificity | Isoform 1 is ubiquitously expressed. {ECO:0000269|PubMed:19509291}. |
FAM59A CRISPR/Cas9 KO Plasmid (h) - sc-416601 from Santa Cruz Biotechnology
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FAM59A HDR Plasmid (h) - sc-416601-HDR from Santa Cruz Biotechnology
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FAM59A Double Nickase Plasmid (h) - sc-416601-NIC from Santa Cruz Biotechnology
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FAM59A Double Nickase Plasmid (h2) - sc-416601-NIC-2 from Santa Cruz Biotechnology
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FAM59A CRISPR Activation Plasmid (h) - sc-416601-ACT from Santa Cruz Biotechnology
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FAM59A CRISPR Activation Plasmid (h2) - sc-416601-ACT-2 from Santa Cruz Biotechnology
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FAM59A Lentiviral Activation Particles (h) - sc-416601-LAC from Santa Cruz Biotechnology
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FAM59A Lentiviral Activation Particles (h2) - sc-416601-LAC-2 from Santa Cruz Biotechnology
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FAM59A siRNA (h) - sc-77308 from Santa Cruz Biotechnology
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FAM59A shRNA Plasmid (h) - sc-77308-SH from Santa Cruz Biotechnology
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FAM59A shRNA (h) Lentiviral Particles - sc-77308-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU028381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8364 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8364 from Sigma-Aldrich
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GAREM siRNA (Human) - CRJ2071 from Cohesion Biosciences
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GAREM - MBS8220179 from MyBioSource
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shRNA set against Human FAM59A (NM_022751.2) - SHH291405 from Creative biogene
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GAREM shRNA Plasmid (Human) - CHJ2071 from Cohesion Biosciences
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FAM59A miRNA 3'UTR clone - MiUTR3H-14888 from Creative biogene
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