JPH2

Gene Symbol	JPH2
Entrez Gene	57158
Alt Symbol	CMH17, JP-2, JP2
Species	Human
Gene Type	protein-coding
Description	junctophilin 2
Other Description	junctophilin type 2|junctophilin-2
Swissprots	Q5JY74 Q9BR39 Q9UJN4 O95913 E1P5X1
Accessions	EAW75940 EAW75941 EAW75942 EAW75943 Q9BR39 AK098288 AK098303 AK304863 BAG65601 AL132999 CAB61347 AW014086 BC029957 BC043206 AAH43206 BC172751 AAI72751 XM_006723832 XP_006723895 XM_006723833 XP_006723896 NM_020433 NP_065166 NM_175913 NP_787109
Function	Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions. {ECO:0000269|PubMed:20095964}.
Subcellular Location	Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands (By similarity). {ECO:0000250}.
Tissue Specificity	Specifically expressed in skeletal muscle and heart. {ECO:0000269|PubMed:10891348}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Junctophilin-2 peptide - ab110064 from Abcam Category Peptide

Junctophilin 2 / JPH2 Antibody Blocking Peptide - LS-E2431 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Junctophilin 2 / JPH2 Antibody Blocking Peptide - LS-E25186 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Junctophilin 2 / JPH2 Antibody Blocking Peptide - LS-E18493 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Junctophilin 2 / JPH2 Antibody Blocking Peptide - LS-E30611 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Junctophilin 2 / JPH2 Antibody Blocking Peptide - LS-E30615 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

JPH2-Antibody-C-term-Blocking-peptide - BP13445b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

JPH2 Peptide - GTX85364-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

JPH2 Peptide - GTX85367-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Jph2 Blocking Peptide - 33R-10384 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Junctophilin 2 Blocking Peptide - 33R-1407 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Junctophilin-2 / JPH2 Control Peptide - AP30468CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Junctophilin-2 / JPH2 Control Peptide - AP30469CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

JPH2 Peptide - 4919P from ProSci Category Peptide Species Human

JPH2 Peptide - 4929P from ProSci Category Peptide Species Human

Recombinant Human Junctophilin-2(JPH2) - CSB-YP866263HU CSB-EP866263HU CSB-BP866263HU CSB-MP866263HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Junctophilin-2 / JPH2 (transcript variant 1) - TP319661 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

JPH2 Peptide, Human - M34GP07871H from Creative Peptides Category Peptide Source Synthetic. Species Human

JPH2 Recombinant Protein Antigen - NBP2-30961PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Junctophilin-2 (JPH2), Recombinant Protein - MBS1352826 from MyBioSource Category Protein Prices $1,475.00, $1,475.00, $1,705.00, $1,705.00, $2,515.00, $2,515.00, $2,960.00, $2,960.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human JPH2 Protein, MYC/DDK-tagged - JPH2-786H from Creative Biomart Category Protein Source HEK293 Species Human

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