JPH2

Gene Symbol JPH2
Entrez Gene 57158
Alt Symbol CMH17, JP-2, JP2
Species Human
Gene Type protein-coding
Description junctophilin 2
Other Description junctophilin type 2|junctophilin-2
Swissprots Q5JY74 Q9BR39 Q9UJN4 O95913 E1P5X1
Accessions EAW75940 EAW75941 EAW75942 EAW75943 Q9BR39 AK098288 AK098303 AK304863 BAG65601 AL132999 CAB61347 AW014086 BC029957 BC043206 AAH43206 BC172751 AAI72751 XM_006723832 XP_006723895 XM_006723833 XP_006723896 NM_020433 NP_065166 NM_175913 NP_787109
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions. {ECO:0000269|PubMed:20095964}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes. In skeletal muscle, it is specifically localized at the junction of A and I bands (By similarity). {ECO:0000250}.
Tissue Specificity Specifically expressed in skeletal muscle and heart. {ECO:0000269|PubMed:10891348}.

Junctophilin-2 (A-1) - sc-398290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Junctophilin-2 (A-1): sc-398290. Western blot analysis of Junctophilin-2 expression in human heart (A) and human skeletal muscle (B) tissue extracts.

Junctophilin-2 (B-6) - sc-398125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Junctophilin-2 (B-6): sc-398125. Western blot analysis of Junctophilin-2 expression in human heart (A) and human skeletal muscle (B) tissue extracts.

Junctophilin-2 (D-11) - sc-398457 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Junctophilin-2 (D-11): sc-398457. Western blot analysis of Junctophilin-2 expression in human heart tissue extract.

Junctophilin-2 (H-3) - sc-377086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Junctophilin-2 (H-3): sc-377086. Western blot analysis of Junctophilin-2 expression in rat skeletal muscle (A) and rat heart (B) tissue extracts.

Junctophilin-2 (H-250) - sc-134875 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Junctophilin-2 (Y-15) - sc-51313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Junctophilin-2 (Y-15): sc-51313. Western blot analysis of Junctophilin-2 expression in rat heart (A), rat skeletal muscle (B) and mouse heart (C) tissue extracts.

Junctophilin-2 (S-14) - sc-51311 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Junctophilin-2 antibody - ab79071 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Junctophilin-2 antibody (ab79071) at 1 µg/mlLane 2 : Anti-Junctophilin-2 antibody (ab79071) at 2 µg/mlLane 1 : mouse brain tissue lysateLane 2 : mouse brain tissue lysateLysates/proteins at 15 µg per lane.

Anti-Junctophilin-2 antibody - ab110056 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Junctophilin-2 antibody (ab110056) at 1 µg/mlLane 2 : Anti-Junctophilin-2 antibody (ab110056) at 2 µg/mlLane 1 : Mouse brain tissue lysate Lane 2 : Mouse brain tissue lysate

Anti-Junctophilin-2 antibody - ab116136 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Junctophilin-2 antibody (ab116136) at 1/100 dilution + ZR-75-1 cell line lysate at 35 µg

Anti-Junctophilin-2 antibody - ab116077 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Junctophilin-2 antibody (ab116077) at 1 mg/ml + Mouse pancreas lysate at 10 µg

Anti-Junctophilin-2 antibody [1F5] - ab180362 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F5
All lanes : Anti-Junctophilin-2 antibody [1F5] (ab180362) at 1/4000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNA for 48 hrs and lysedLane 2 : HEK293T cells transfected with pCMV6-ENTRY Junctophilin-2 cDNA for 48 hrs and lysedLysates/proteins at 5 µg per lane.SecondaryGoat anti-mouse-HRP at 1/5000 dilution

Anti-Junctophilin 2 / JPH2 Antibody (aa614-643, AP) - LS-C215328 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Junctophilin 2 / JPH2 Antibody (aa614-643, APC) - LS-C215329 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Junctophilin 2 / JPH2 Antibody (aa614-643, Biotin) - LS-C215330 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Junctophilin 2 / JPH2 Antibody (aa614-643, FITC) - LS-C215331 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Junctophilin 2 / JPH2 Antibody (aa614-643, Azide-free, HRP) - LS-C215332 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Junctophilin 2 / JPH2 Antibody (C-Terminus) - LS-C82883 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of JPH2 in 293 cell lysate with JPH2 antibody at 2 ug/ml in (A) the absence and (B) the presence of blocking peptide

Anti-Junctophilin 2 / JPH2 Antibody (aa613-643) - LS-C322336 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Junctophilin 2 / JPH2 Antibody (aa614-643, PE) - LS-C215333 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Junctophilin 2 / JPH2 Antibody (aa408-457) - LS-C81642 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal muscle cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-Junctophilin 2 / JPH2 Antibody (aa614-643) - LS-C165372 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
JPH2 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The JPH2 antibody detected the JPH2 protein (arrow).

Anti-Junctophilin 2 / JPH2 Antibody (clone 1E1) - LS-C338295 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY JPH2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-JPH2.

Anti-Junctophilin 2 / JPH2 Antibody (clone 2E5) - LS-C338296 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY JPH2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-JPH2.

Anti-Junctophilin 2 / JPH2 Antibody (clone 2D3) - LS-C338322 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY JPH2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-JPH2.
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