BRCA2

Gene Symbol	BRCA2
Entrez Gene	675
Alt Symbol	BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11
Species	Human
Gene Type	protein-coding
Description	breast cancer 2, early onset
Other Description	BRCA1/BRCA2-containing complex, subunit 2|Fanconi anemia group D1 protein|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer type 2 susceptibility protein
Swissprots	Q13879 O00183 Q5TBJ7 O15008 P51587
Accessions	AAG32681 AAG32682 AAG46030 AAK29432 AAN28944 AAN61409 AAN61410 AAN61411 AAN61412 AAN61413 AAN61414 AAN61415 AAN61416 AAN61417 AAN61418 AAN61419 AAN61420 AAN61421 AAN61422 AAN61426 AAN61427 AAN61428 AAN61429 AAN61430 AAN61431 AAN61432 AAN61433 AAN61434 AAN61435 AAN61436 AAN61437 AAQ97181 AAZ22546 ABJ90481 ACD01217 AIC83529 AIC83530 AIC83531 AIC83532 AIC83533 AIC83534 AIC83535 AIC83536 AIC83537 AIC83538 AIC83543 AIC83560 AIC83561 AIC83562 AIC83563 AIC83564 AIC83565 AIC83566 AIC83567 AIC83568 AIC83569 AIC83570 AIC83583 AIC83584 AIC83585 AIC83586 AIC83587 AIC83588 AIY60806 AKE50582 AKE50583 AKE50584 AKE50585 AKE50586 AKE50587 AKE50588 AKE50589 AKE50590 AKE50591 AKE50592 AKE50593 AKE50594 AKE50595 CAA64484 CAA97728 CAA98995 EAX08499 EAX08500 EAX08501 P51587 BC026160 BC047568 DQ897648 ABI74674 GU014835 ACX32322 JX480468 AFU88810 JX480469 AFU88811 JX480470 AFU88812 JX480471 AFU88813 JX480472 AFU88814 JX480473 AFU88815 JX480474 AFU88816 JX480475 AFU88817 JX480476 AFU88818 JX480477 AFU88819 JX480478 AFU88820 U43746 AAB07223 XM_011535203 XP_011533505 XM_011535204 XP_011533506 XM_011535205 XP_011533507 NM_000059 NP_000050
Function	Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) s
Subcellular Location	Nucleus {ECO:0000305|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.
Tissue Specificity	Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
Top Pathways	Homologous recombination, Pancreatic cancer, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BRCA2 peptide - ab69799 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human BRCA2 (unmodified T3349) peptide - ab36510 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human BRCA2 protein fragment - ab112253 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BRCC2 Protein - GTX111022-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

BRCA2 protein - orb171536 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect cells Species Human

BRCA2 Blocking Peptide - 33R-10871 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

BRCA2 Blocking Peptide - abx062044 from Abbexa Category Peptide Species Human, Rat, Monkey

Human BRCA2 Protein - abx065607 from Abbexa Category Protein Source E.coli Species Human

BRCA2 / FANCD1 - H00000675-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BRCA2 / FANCD1 - H00000675-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human BRCA2 - BRCA2-27673TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human BRCA2 - BRCA2-231H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Human BRCA2, His & GST-tagged - BRCA2-232H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Breast Cancer Susceptibility Protein 2 (BRCA2) - RPB364Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Breast Cancer Susceptibility Protein 2 (BRCA2) - RPB364Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Breast Cancer Susceptibility Protein 2 (BRCA2) - RPB364Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Breast Cancer Susceptibility Protein 2 (BRCA2) - RPB364Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

BRCA2 Blocking Peptide - CBP3150 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat, Monkey

BRCA2 (N60) Peptide - BS2864P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Breast Cancer Susceptibility Protein 2 (BRCA2) - RPB364Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Presenilin 1 (PSEN1) - RPC200Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Breast cancer type 2 susceptibility protein(BRCA2) ,partial - CSB-YP002796HU CSB-EP002796HU CSB-BP002796HU CSB-MP002796HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BRCA2 Blocking Peptide - 3675BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

Recombinant Human BRCA2 Protein - H00000675-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BRCA2 Peptide - abx165209 from Abbexa Category Peptide Species Human, Mouse, Bovine

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