TSC22D3

Gene Symbol TSC22D3
Entrez Gene 1831
Alt Symbol DIP, DSIPI, GILZ, TSC-22R, hDIP
Species Human
Gene Type protein-coding
Description TSC22 domain family, member 3
Other Description DSIP-immunoreactive leucine zipper protein|DSIP-immunoreactive peptide|TSC-22 related protein|TSC-22-like protein|TSC-22-related protein|TSC22 domain family protein 3|delta sleep inducing peptide, immunoreactor|delta sleep-inducing peptide immunoreactor|glucocorticoid-induced leucine zipper protein
Swissprots Q5H9S3 Q99576 Q6FIH6 Q5JRI9 Q9UG13 Q8WVB9 Q8NAI1 Q9UBN5
Accessions EAX02704 EAX02705 EAX02706 EAX02707 EAX02708 Q99576 AB025432 BAB18680 AF153603 AAD41085 AF183393 AAD56234 AF228339 AAG12456 AK092645 BAC03934 AK092669 BAG52587 AK127938 BAG54599 AK300535 BAG62243 AK311834 BAG34776 AL110191 CAB53669 AY007119 BC018148 AAH18148 BC072446 AAH72446 BM047061 BQ919216 BX647854 CR533450 CAG38481 CR933650 CAI45951 EU831656 ACE87256 EU831739 ACE86573 Z50781 CAA90644 XM_005262098 XP_005262155 XM_005262099 XP_005262156 XM_005262100 XP_005262157 XM_005262101 XP_005262158 XM_005262102 XP_005262159 XM_005262103 XP_005262160 XM_006724629 XP_006724692 XM_011530884 XP_011529186 NM_001015881 NP_001015881 NM_004089 NP_004080 NM_198057 NP_932174
Function Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity). {ECO:0000250}.
Subcellular Location Isoform 1: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down- regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells. {ECO:0000269|PubMed:11313722, ECO:0000269|PubMed:12393603}.

GILZ (FL-134) - sc-33780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GILZ (FL-134): sc-33780. Western blot analysis of GILZ expression in non-transfected: sc-110760 (A) and human GILZ transfected: sc-112944 (B) 293 whole cell lysates.

GILZ (C-17) - sc-26520 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GILZ (C-17): sc-26520. Western blot analysis of GILZ expression in non-transfected: sc-117752 (A) and human GILZ transfected: sc-111443 (B) 293T whole cell lysates.

GILZ (S-15) - sc-26519 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GILZ (G-5) - sc-133215 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GILZ (G-5): sc-133215. Western blot analysis of GILZ expression in non-transfected: sc-117752 (A) and human GILZ transfected: sc-111443 (B) 293T whole cell lysates.

GILZ (N-18) - sc-26518 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GILZ (D-2) - sc-133216 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GILZ (D-2): sc-133216. Western blot analysis of GILZ expression in non-transfected: sc-117752 (A) and human GILZ transfected: sc-111443 (B) 293T whole cell lysates.

Anti-GilZ / TilZ antibody - ab55015 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HeLa cells stained with ab55015 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab55015, 0.01μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-GilZ / TilZ antibody - ab197987 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling GilZ / TilZ with ab197987 at 1/40 dilution.

Anti-GilZ / TilZ antibody - ab171890 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-GilZ / TilZ antibody (ab171890) at 1 µg/mlLane 1 : GilZ / TilZ transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-GilZ / TilZ antibody - ab130301 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GilZ / TilZ antibody (ab130301) at 1/100 dilution + Mouse kidney tissue lysate at 35 µg

Anti-GilZ / TilZ antibody [3A5] - ab117085 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3A5
ab117085, at 5 µg/ml, staining GilZ / TilZ in Formalin-fixed, Paraffin-embedded Human Breast tissue by Immunohistochemistry.

Anti-TSC22D3 / GILZ Antibody (N-Terminus) IHC-plus™ - LS-B10077 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TSC22D3 / GILZ antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10077 concentration 10 ug/ml.

Anti-TSC22D3 / GILZ Antibody (clone 3A5) IHC-plus™ - LS-B4313 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3A5
Anti-TSC22D3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4313 concentration 5 ug/ml.

Anti-TSC22D3 / GILZ Antibody (clone 1F11) - LS-C174166 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TSC22D3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TSC22D3.

Anti-TSC22D3 / GILZ Antibody (aa62-91) - LS-C160246 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TSC22D3 Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The TSC22D3 antibody detected the TSC22D3 protein (arrow).

Anti-TSC22D3 / GILZ Antibody (aa61-91, AP) - LS-C224481 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSC22D3 / GILZ Antibody (aa61-91, APC) - LS-C224483 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSC22D3 / GILZ Antibody (clone CFMKG15) - LS-C106408 from LifeSpan Bioscience

Prices $225.00, $345.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone CFMKG15
Western Blot of human PBMC cultured without (lane 1) or with (lane 2) dexamethasone (10-7 M) for 3 hr. The membrane was probed with 2 ug/mL anti-mouse/human GILZ (CFMKG15), followed by HRP-conjugated anti-rat IgG.

Anti-TSC22D3 / GILZ Antibody (aa61-91, Biotin) - LS-C224484 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSC22D3 / GILZ Antibody (aa61-91, FITC) - LS-C224485 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSC22D3 / GILZ Antibody (aa61-91, Azide-free, HRP) - LS-C224486 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSC22D3 / GILZ Antibody (aa61-91, PE) - LS-C224487 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSC22D3 / GILZ Antibody (clone 3F3) - LS-C174287 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F3
Anti-TSC22D3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TSC22D3.

Anti-TSC22D3 / GILZ Antibody (clone 5D3) - LS-C174296 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TSC22D3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TSC22D3.

Anti-TSC22D3 / GILZ Antibody (aa1-134, Biotin) - LS-C297563 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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