| Gene Symbol |
CDH2
|
| Entrez Gene |
1000
|
| Alt Symbol |
CD325, CDHN, CDw325, NCAD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cadherin 2, type 1, N-cadherin (neuronal)
|
| Other Description |
N-cadherin 1|cadherin 2, N-cadherin (neuronal)|cadherin-2|calcium-dependent adhesion protein, neuronal|neural cadherin|neural-cadherin
|
| Swissprots |
Q14923 Q8N173 B0YIY6 A8MWK3 P19022
|
| Accessions |
ACA05964 CAA81799 CCD32808 CCE25962 EAX01239 EAX01240 EAX01241 P19022 AA661623 AI675151 AI752179 AI752180 AK302831 BAH13814 AW016710 BC021695 BC036470 AAH36470 BG197310 BX648579 CB105441 CN263272 DA225616 DC403359 EU832318 ACE87575 EU832403 ACE86888 M34064 AAA03236 S42303 AAB22854 X54315 CAA38213 X57548 CAA40773 XM_005258181 XP_005258238 XM_005258182 XP_005258239 XM_011525787 XP_011524089 XM_011525788 XP_011524090 NM_001308176 NP_001295105 NM_001792 NP_001783
|
| Function |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Cell adhesion molecules (CAMs), Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|