Gene Symbol | MARCH9 |
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Entrez Gene | 92979 |
Alt Symbol | MARCH-IX, RNF179 |
Species | Human |
Gene Type | protein-coding |
Description | membrane-associated ring finger (C3HC4) 9 |
Other Description | E3 ubiquitin-protein ligase MARCH9|RING finger protein 179|membrane-associated RING finger protein 9|membrane-associated RING-CH protein IX |
Swissprots | Q86YJ5 B2R9U9 Q86VN5 Q96GG2 |
Accessions | EAW97063 EAW97064 EAW97065 Q86YJ5 AK093897 BAC04247 AK313925 BAG36646 BC009489 AAH09489 BC036455 AAH36455 BC050397 AAH50397 XM_011539007 XP_011537309 NM_138396 NP_612405 |
Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:17174307}. |
Subcellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:14722266}. |
MARCH9 CRISPR/Cas9 KO Plasmid (h) - sc-410240 from Santa Cruz Biotechnology
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MARCH9 HDR Plasmid (h) - sc-410240-HDR from Santa Cruz Biotechnology
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MARCH9 Double Nickase Plasmid (h) - sc-410240-NIC from Santa Cruz Biotechnology
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MARCH9 Double Nickase Plasmid (h2) - sc-410240-NIC-2 from Santa Cruz Biotechnology
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MARCH9 CRISPR Activation Plasmid (h) - sc-410240-ACT from Santa Cruz Biotechnology
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MARCH9 CRISPR Activation Plasmid (h2) - sc-410240-ACT-2 from Santa Cruz Biotechnology
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MARCH9 Lentiviral Activation Particles (h) - sc-410240-LAC from Santa Cruz Biotechnology
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MARCH9 Lentiviral Activation Particles (h2) - sc-410240-LAC-2 from Santa Cruz Biotechnology
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MARCH9 siRNA (h) - sc-95940 from Santa Cruz Biotechnology
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MARCH9 shRNA Plasmid (h) - sc-95940-SH from Santa Cruz Biotechnology
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MARCH9 shRNA (h) Lentiviral Particles - sc-95940-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU154961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13038 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13038 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07689 from Sigma-Aldrich
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MARCH9 siRNA (Human) - CRJ4179 from Cohesion Biosciences
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MARCH9 RNAi - H00092979-R01 from Novus Biologicals
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shRNA set against Human MARCH9 (NM_138396.5) - SHH338311 from Creative biogene
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MARCH9 shRNA Plasmid (Human) - CHJ4179 from Cohesion Biosciences
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MARCH9 miRNA 3'UTR clone - MiUTR3H-12851 from Creative biogene
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