Gene Symbol | CHCHD3 |
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Entrez Gene | 54927 |
Alt Symbol | MINOS3, PPP1R22 |
Species | Human |
Gene Type | protein-coding |
Description | coiled-coil-helix-coiled-coil-helix domain containing 3 |
Other Description | MICOS complex subunit MIC19|coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial|mitochondrial inner membrane organizing system 3|protein phosphatase 1, regulatory subunit 22 |
Swissprots | Q9NX63 |
Accessions | EAL24074 EAW83800 EAW83801 EAW83802 EAW83803 Q9NX63 AK000427 BAA91157 AK129533 AK294071 BAH11665 AK310236 BC011596 AAH11596 BC014839 AAH14839 HQ447383 ADQ31869 XM_011516363 XP_011514665 XM_011516364 XP_011514666 XM_011516365 XP_011514667 NM_017812 NP_060282 |
Function | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. {ECO:0000269|PubMed:22567091}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Intermembrane side {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:22567091}. Nucleus {ECO:0000269|PubMed:22567091}. |
Tissue Specificity | Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue. {ECO:0000269|PubMed:22567091}. |
CHCHD3 CRISPR/Cas9 KO Plasmid (h) - sc-408682 from Santa Cruz Biotechnology
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CHCHD3 HDR Plasmid (h) - sc-408682-HDR from Santa Cruz Biotechnology
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CHCHD3 Double Nickase Plasmid (h) - sc-408682-NIC from Santa Cruz Biotechnology
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CHCHD3 Double Nickase Plasmid (h2) - sc-408682-NIC-2 from Santa Cruz Biotechnology
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CHCHD3 CRISPR Activation Plasmid (h) - sc-408682-ACT from Santa Cruz Biotechnology
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CHCHD3 CRISPR Activation Plasmid (h2) - sc-408682-ACT-2 from Santa Cruz Biotechnology
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CHCHD3 Lentiviral Activation Particles (h) - sc-408682-LAC from Santa Cruz Biotechnology
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CHCHD3 Lentiviral Activation Particles (h2) - sc-408682-LAC-2 from Santa Cruz Biotechnology
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CHCHD3 siRNA (h) - sc-89555 from Santa Cruz Biotechnology
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CHCHD3 shRNA Plasmid (h) - sc-89555-SH from Santa Cruz Biotechnology
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CHCHD3 shRNA (h) Lentiviral Particles - sc-89555-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6034 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6034 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06821 from Sigma-Aldrich
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CHCHD3 siRNA (Human) - CRJ0330 from Cohesion Biosciences
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CHCHD3 - MBS829272 from MyBioSource
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shRNA set against Human CHCHD3(NM_017812.2) - SHG173539 from Creative biogene
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Human CHCHD3 siRNA - orb270831 from Biorbyt
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CHCHD3 shRNA Plasmid (Human) - CHJ0330 from Cohesion Biosciences
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CHCHD3 miRNA 3'UTR clone - MiUTR3H-13030 from Creative biogene
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