| Gene Symbol |
CHCHD3
|
| Entrez Gene |
54927
|
| Alt Symbol |
MINOS3, PPP1R22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coiled-coil-helix-coiled-coil-helix domain containing 3
|
| Other Description |
MICOS complex subunit MIC19|coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial|mitochondrial inner membrane organizing system 3|protein phosphatase 1, regulatory subunit 22
|
| Swissprots |
Q9NX63
|
| Accessions |
EAL24074 EAW83800 EAW83801 EAW83802 EAW83803 Q9NX63 AK000427 BAA91157 AK129533 AK294071 BAH11665 AK310236 BC011596 AAH11596 BC014839 AAH14839 HQ447383 ADQ31869 XM_011516363 XP_011514665 XM_011516364 XP_011514666 XM_011516365 XP_011514667 NM_017812 NP_060282
|
| Function |
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. {ECO:0000269|PubMed:22567091}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Intermembrane side {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:22567091}. Nucleus {ECO:0000269|PubMed:22567091}.
|
| Tissue Specificity |
Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue. {ECO:0000269|PubMed:22567091}.
|