| Gene Symbol | PPAP2B |
|---|---|
| Entrez Gene | 8613 |
| Alt Symbol | Dri42, LPP3, PAP2B, VCIP |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidic acid phosphatase type 2B |
| Other Description | PAP2 beta|lipid phosphate phosphohydrolase 3|phosphatidate phosphohydrolase type 2b|type-2 phosphatidic acid phosphatase-beta|vascular endothelial growth factor and type I collagen inducible |
| Swissprots | Q99782 Q96GW0 O14495 Q5U0F7 D3DQ52 B2R651 |
| Accessions | EAX06651 EAX06652 EAX06653 O14495 AB000889 BAA22594 AF017786 AAC63433 AF043329 AAD02271 AF480883 AAO84481 AK123105 AK312439 BAG35348 BC009196 AAH09196 BM471786 BM719257 BQ027458 BT019589 AAV38396 BU608248 BU616092 DA580891 DQ893521 ABM84447 DQ895944 ABM86870 U79294 AAB50222 NM_003713 NP_003704 NM_177414 |
| Function | Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions. |
| Subcellular Location | Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart and placenta. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Fat digestion and absorption, Choline metabolism in cancer, Ether lipid metabolism, Glycerolipid metabolism |