CA2

Gene Symbol CA2
Entrez Gene 760
Alt Symbol CA-II, CAC, CAII, Car2, HEL-76
Species Human
Gene Type protein-coding
Description carbonic anhydrase II
Other Description carbonate dehydratase II|carbonic anhydrase 2|carbonic anhydrase B|carbonic anhydrase C|carbonic dehydratase|epididymis luminal protein 76
Swissprots Q96ET9 P00918 Q6FI12 B2R7G8
Accessions AAA51909 CAA27012 EAW87136 P00918 AF015039 AK123309 AK312978 BAG35815 BC011949 AAH11949 BC035424 CD013933 CR536526 CAG38763 CR541875 CAG46673 DA431650 DQ891320 ABM82246 DQ894504 ABM85430 FJ224289 ACI45981 J03037 AAA51908 M36532 AAA51911 S69526 AAB30170 Y00339 CAA68426 NM_000067 NP_000058 NM_001293675 NP_001280604
Function Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000250, ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:15990874}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.
Top Pathways Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion

CA2 Antibody - 8612 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 and MCF7 cells using CA2 Antibody.

CA II (C-10) - sc-166547 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CA II (C-10): sc-166547. Western blot analysis of CA II expression in c4 whole cell lysate.

CA II (C-14) - sc-17246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CA II (C-14): sc-17246. Immunofluorescence staining of methanol-fixed KNRK cells showing cytoplasmic staining.

CA II (D-8) - sc-133111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CA II (D-8): sc-133111. Western blot analysis of CA II expression in non-transfected 293T: sc-117752 (A), human CA II transfected 293T: sc-113038 expression vector (B) and HEL 92.1.7 (C) whole cell lysates.

CA II (G-2) - sc-48351 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CA II (G-2): sc-48351. Western blot analysis of CA II expression in non-transfected: sc-110760 (A) and human CA II transfected: sc-113038 (B) 293 whole cell lysates and mouse kindey tissue extract (C).

CA II (D-11) - sc-166569 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CA II (D-11): sc-166569. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

CA II (H-10) - sc-133110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CA II (H-10): sc-133110. Western blot analysis of CA II expression in non-transfected: sc-117752 (A) and human CA II transfected: sc-113038 expression vector (B) 293T whole cell lysates.

CA II (M-14) - sc-17244 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CA II (M-14): sc-17244. Western blot analysis of CA II expression in mouse kidney tissue extract.

CA II (H-70) - sc-25596 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CA II (H-70): sc-25596. Western blot analysis of CA II expression in non-transfected: sc-110760 (A) and human CA II transfected: sc-113038 (B) 293 whole cell lysates and mouse kindey tissue extract (C).

CA II (N-16) - sc-17242 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CA II (N-16): sc-17242. Western blot analysis of CA II expression in mouse kidney tissue extract.

Anti-Carbonic Anhydrase II antibody - ab6621 from Abcam

Host Rabbit
Clonality Polyclonal
Observed band size : 30 kDa (why is the actual band size different from the predicted?)This image is courtesy of an anonymous AbreviewSee Abreview

Anti-Carbonic Anhydrase II antibody - ab191343 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Carbonic Anhydrase II antibody - ab182611 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling Carbonic Anhydrase II with ab182611 at a 1/20 dilution, on the right is treated with the fusion protein.

Anti-Carbonic Anhydrase II antibody (Biotin) - ab34675 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Carbonic Anhydrase II antibody [EPR5195] - ab124687 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5195
All lanes : Anti-Carbonic Anhydrase II antibody [EPR5195] (ab124687) at 1/1000 dilutionLane 1 : Human fetal brain tissue lysateLane 2 : Caco 2 cell lysateLane 3 : 293T cell lysateLane 4 : Human heart tissue lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Carbonic Anhydrase II antibody - C-terminal - ab135279 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Carbonic Anhydrase II antibody - C-terminal (ab135279) at 1/500 dilution + Rat heart cell lysate at 30 µg

Anti-CA2 / Carbonic Anhydrase II Antibody - LS-C293138 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Guinea Pig
Clonality Polyclonal

Anti-CA2 / Carbonic Anhydrase II Antibody - LS-C293139 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CA2 / Carbonic Anhydrase II Antibody - LS-C293141 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CA2 / Carbonic Anhydrase II Antibody - LS-C192711 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of various cell lines, using CA2 antibody.

Anti-CA2 / Carbonic Anhydrase II Antibody (aa1-260) - LS-C292389 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant CA2 / Carbonic Anhydrase II.

Anti-CA2 / Carbonic Anhydrase II Antibody (aa1-260) - LS-C293133 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CA2 / Carbonic Anhydrase II.

Anti-CA2 / Carbonic Anhydrase II Antibody (aa1-260) - LS-C293137 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CA2 / Carbonic Anhydrase II.

Anti-CA2 / Carbonic Anhydrase II Antibody IHC-plus™ - LS-B1439 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Carbonic Anhydrase II antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1439 concentration 5 ug/ml.

Anti-CA2 / Carbonic Anhydrase II Antibody (aa1-260, Biotin) - LS-C297402 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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