Gene Symbol | Pla2g2a |
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Entrez Gene | 18780 |
Alt Symbol | EF, Mom1, Pla2, sPLA2, sPla2-IIA |
Species | Mouse |
Gene Type | protein-coding |
Description | phospholipase A2, group IIA (platelets, synovial fluid) |
Other Description | GIIC sPLA2|enhancing factor|group IIA phospholipase A2|modifier of Min1|non-pancreatic secreted type II phospholipase A2|phosphatidylcholine 2-acylhydrolase 2A|phospholipase A2 group IIa|phospholipase A2, membrane associated|secretory group II phospholipase A2 |
Swissprots | Q60871 P31482 |
Accessions | AAC52252 AHB62392 P31482 AK131857 BC045156 AAH45156 CB933893 U28244 AAB06315 U32359 AAB60494 X74266 CAA52325 NM_001082531 NP_001076000 NR_002926 NM_011108 |
Function | May play a role in cell proliferation, by increasing the binding of EGF to the cells and thereby modulating its action. In doing so, this isozyme binds to a membrane-associated receptor distinct from the EGF receptor and which could be a heparan- sulfate proteoglycan located on the cell membrane. |
Subcellular Location | Membrane; Peripheral membrane protein. |
Tissue Specificity | Mainly in the Paneth cells adjacent to the stem population in the small intestines. Also expressed in regenerating liver and hyperplastic esophageal epithelium. |
Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group II sPLA 2 CRISPR/Cas9 KO Plasmid (m) - sc-422281 from Santa Cruz Biotechnology
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group II sPLA 2 HDR Plasmid (m) - sc-422281-HDR from Santa Cruz Biotechnology
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group II sPLA 2 Double Nickase Plasmid (m) - sc-422281-NIC from Santa Cruz Biotechnology
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group II sPLA 2 Double Nickase Plasmid (m2) - sc-422281-NIC-2 from Santa Cruz Biotechnology
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group II sPLA 2 CRISPR Activation Plasmid (m) - sc-422281-ACT from Santa Cruz Biotechnology
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group II sPLA 2 CRISPR Activation Plasmid (m2) - sc-422281-ACT-2 from Santa Cruz Biotechnology
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group II sPLA 2 Lentiviral Activation Particles (m) - sc-422281-LAC from Santa Cruz Biotechnology
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group II sPLA 2 Lentiviral Activation Particles (m2) - sc-422281-LAC-2 from Santa Cruz Biotechnology
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group II sPLA 2 siRNA (m) - sc-43818 from Santa Cruz Biotechnology
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group II sPLA 2 shRNA Plasmid (m) - sc-43818-SH from Santa Cruz Biotechnology
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group II sPLA 2 shRNA (m) Lentiviral Particles - sc-43818-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN38818 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38818 from Sigma-Aldrich
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PLA2G2A siRNA (Mouse) - CRM3103 from Cohesion Biosciences
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shRNA set against Mouse PLA2G2A (NM_001082531.1) - SHH376740 from Creative biogene
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shRNA set against Mouse Pla2g2a(NM_001082531.1) - SHR118106 from Creative biogene
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Mouse PLA2G2A siRNA - orb282579 from Biorbyt
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PLA2G2A shRNA Plasmid (Mouse) - CHM3103 from Cohesion Biosciences
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PLA2G2A miRNA 3'UTR clone - MiUTR1M-09280 from Creative biogene
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