| Gene Symbol |
Pla2g2a
|
| Entrez Gene |
18780
|
| Alt Symbol |
EF, Mom1, Pla2, sPLA2, sPla2-IIA
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group IIA (platelets, synovial fluid)
|
| Other Description |
GIIC sPLA2|enhancing factor|group IIA phospholipase A2|modifier of Min1|non-pancreatic secreted type II phospholipase A2|phosphatidylcholine 2-acylhydrolase 2A|phospholipase A2 group IIa|phospholipase A2, membrane associated|secretory group II phospholipase A2
|
| Swissprots |
Q60871 P31482
|
| Accessions |
AAC52252 AHB62392 P31482 AK131857 BC045156 AAH45156 CB933893 U28244 AAB06315 U32359 AAB60494 X74266 CAA52325 NM_001082531 NP_001076000 NR_002926 NM_011108
|
| Function |
May play a role in cell proliferation, by increasing the binding of EGF to the cells and thereby modulating its action. In doing so, this isozyme binds to a membrane-associated receptor distinct from the EGF receptor and which could be a heparan- sulfate proteoglycan located on the cell membrane.
|
| Subcellular Location |
Membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Mainly in the Paneth cells adjacent to the stem population in the small intestines. Also expressed in regenerating liver and hyperplastic esophageal epithelium.
|
| Top Pathways |
Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism
|
